DNA methylation plays a critical role in the regulation of gene expression and has been implicated in the etiology of many human diseases including cancer. Methylation profiling with BeadArray technology allows researchers to analyze the effects of aberrant methylation (either hyper- or hypomethylation) for a variety of applications. Illumina has developed a robust methylation profiling platform that provides quantitative methylation measurement at the single-CpG-site level, providing the highest resolution for understanding epigenetic changes.LEARN MORE
With Infinium Methylation Assays, researchers can quantitatively interrogate methylation sites at single-nucleotide resolution, profiling up to 12 samples in parallel to deliver high-throughput power while minimizing the cost per sample. The HumanMethylation450 BeadChip offers a unique combination of comprehensive, expert-selected coverage of >450,000 methylation sites, high throughput, and low price, making it ideal for screening genome-wide association study (GWAS) populations.