Get a complete view of the epigenome at single-base resolution with the Genome AnalyzerIIx. Whether you are interested in CpG methylation, histone modifications, chromatin structure, or DNA-protein interactions, Illumina's unique sequencing chemistry gives you unbiased coverage of every base in the genome.

Use Illumina's ChIP-Seq protocol to generate accurate and precise DNA-protein interaction maps from a single chromatin immunoprecipitated sample. Map genome-wide methylation patterns by sequencing bisulfite-converted DNA, methylation-sensitive restriction digest-enriched fragments, anti-methyl-C precipitated fragments, or chromatin immunoprecipitates of methyltransferases trapped to aza-labeled DNA.

Learn more about ChIP-Seq and view publications demonstrating how researchers are using Genome AnalyzerIIx system to explore and characterize gene regulation and control.

Highlights

     

  • High Sequencing Accuracy: Achieve true base-by-base sequencing even through homopolymers created by bisulfite conversion

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  • High Sensitivity: Identify a broad range of protein-DNA interactions with confidence, and use millions of counts to differentiate real events from spurious signal

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  • Single-Site Resolution: Detect variations in methylation signatures at single-base resolution; pinpoint rare binding events to within 50 bases of the actual binding site

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  • Mapping Accuracy: Correctly map more reads to the epigenome using accurate 100+ bp paired-end reads

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