Millions of formalin-fixed paraffin-embedded (FFPE) archival cancer tissue samples provide an enormous and invaluable repository of information for cancer research. These samples hold a wealth of data for the discovery of biomarkers, drug development, and diagnosis and treatment of diseases.

However, the fixation process and storage of FFPE samples frequently leads to nucleic acid degradation and base modification. Until recently, degraded DNA from FFPE samples generally resulted in poor performance for genotyping studies using the Infinium HD Assay, as it was inefficiently amplified in the whole-genome amplification step.

To overcome this problem, Illumina has developed a FFPE sample restoration solution that provides a simple workflow to QC samples, repair damaged DNA, and achieve high-quality data using the Infinium HD Assay.

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