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Linkage analysis provides researchers a powerful method for mapping the location of disease-causing loci by identifying genetic markers that are co-inherited with a phenotype of interest. Illumina's linkage analysis BeadChips present the optimal solution for identifying regions of statistically unequivocal linkage by delivering the information content, call rates, and accuracy that enable discovery of links between familial genotype and phenotype in both monogenic and polygenic disorders.
Human Linkage Analysis
Available with the GoldenGate Assay, the HumanLinkage V Panel Set is optimized to detect recombination events. Linkage analysis is a powerful approach for mapping the location of disease-causing loci. The 6,056 HumanLinkage V Panel SNP markers were chosen from highly validated HapMap DNA assays to optimize information content, enabling researchers to extract the greatest amount of data from the least number of markers.
Mouse Linkage Analysis
For mouse genetics applications, two Mouse Linkage Panels — Mouse Low Density (LD) Linkage and Mouse Medium Density (MD) Linkage — are available. Both single nucleotide polymorphism (SNP) panels offer a low-cost, efficient method for attaining genome-wide genetic data to identify quantitative trait loci (QTLs), map candidate genes, and increase genotyping throughput. SNP sequences are optimized for Illumina's proven BeadArray Technology.
At Illumina, our goal is to apply innovative technologies and revolutionary assays to the analysis of genetic variation and function, making studies possible that were not even imaginable just a few years ago. These studies will help make the realization of personalized medicine possible. With such rapid advances in technology taking place, it is mission critical to have solutions that are not only innovative, but flexible, scalable, and complete with industry-leading support and service. As a global company that places high value on collaborative interactions, rapid delivery of solutions, and prioritizing the needs of its customers, we strive to meet this challenge. Illumina's innovative, array-based solutions for DNA, RNA, and protein analysis serve as tools for disease research, drug development, and the development of molecular tests in the clinic.