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Omni Arrays
Dig deeper into your research. Make new discoveries. Tailor your studies.
The new Omni5 harnesses over ten years of genomic research, capturing variation down to 1% MAF. With more than 4.3 million high-value markers. And room for 500k of your own.
It’s the most powerful genotyping array for your whole-genome studies yet. Take a closer look at the Omni5.
Omni Roadmap. Delivered.
Since the Omni family of microarrays was launched in 2009, we’ve offered an expanding selection of flexible arrays featuring only the most informative common and progressively rare variants. Delivering the most powerful markers selected from the International HapMap Project and the 1000 Genomes Project. Built with input from thought leaders in the human genetics research community. To ensure these markers would most effectively advance your studies.
Now the Omni5 is here. This flagship array dramatically expands the catalog of rare variants, offering unprecedented coverage of the genome, including high-value regions that deliver the most power to identify variants associated with disease.
An array for any study. Any budget.
The Omni family gives you the flexibility to study the widest range of genetic variation—no matter your study size, sample population, research focus, or budget. Get the most comprehensive coverage of common and rare variants with the Omni5. Or, start smaller and build your variant collection with Omni products as your study grows.
Wherever you begin, you’re guaranteed to be working with the most robust family of microarrays. All backed by the powerful Infinium Assay. With the highest-throughput. Intelligent tag-SNP selection. Cutting-edge content. All making the most of what this decade of genomic research has revealed. Giving you the power to effectively drive your next-gen GWAS studies—and discoveries.
- Discover the technology »
Watch the Infinium Arrays animation 
- View the video »
Watch recent advancements in human genomics. 
- Launch the chip selector »
Select the best array for your research. 
- Read the e-book »
Read about the evolution of Omni arrays. 
- Explore hybrid workflow options »
Expand the power of your study—next-gen sequencing and arrays.
Applications
Since they were first developed in 2005, whole-genome genotyping arrays have become an invaluable tool for discovering variants that contribute to human diseases and phenotypes. The two primary applications of this technology, genome-wide association studies (GWAS) and copy number variant (CNV) analysis, have helped researchers begin to unravel the complex genetic architecture behind diseases such as diabetes and Crohn’s disease, and traits such as hair and eye color.
GWAS
GWAS has already proven very successful as an analytical approach to help researchers identify regions of the genome that harbor causative alleles for a trait or disease. This is accomplished by evaluating whole-genome genotypes across a large number of DNA samples and identifying those genetic variants that occur more frequently in people with a given trait or disease (cases), relative to those without the trait or disease (controls). Those variants that have statistically significant allele frequencies across the two groups of samples are said to be associated with that phenotype. Once an association is identified, it serves as an indicator to the region of the genome where causative variants are likely to exist. The use of GWAS to uncover these variants has proved immensely successful, identifying thousands of variants in hundreds of publications in a few short years. However, much remains to be discovered as researchers embark on a next-generation of GWAS, using new microarrays that allow detection of rarer variation and expand the catalog of diseases, traits, and populations studied.
Structural Variation Analysis
Structural Variation, is thought to be a significant contributor to the genetic basis of human disease. The same raw signal intensity data that is used to call genotypes can be used to identify regions where the genome contains either increased or decreased gene copy numbers. Furthermore, the added information of genotypes allows researchers to identify copy number neutral loss-of-heterozygosity. Dense marker spacing on the Omni microarrays, coupled with the sensitive Infinium assay and Illumina’s high-precision array scanners, offer researchers a powerful solution for analyzing a range of structural variants.
Omni BeadChips
| BeadChip | Array Format/ Sample Throughput | Markers per Sample | Data Set Used for Content Selection | Content Description |
|---|---|---|---|---|
| HumanOmni5-Quad | 4/460* | 4.3 million + up to 500,000 custom |
1000 Genomes Dec 2010 release (MAF ≥ 1%) |
Access the highest value content, plus add 500K of your own. |
| HumanOmni2.5S | 8/1,067* | ~ 2.5 million + up to 500,000 custom |
1000 Genomes Dec 2010 release (MAF ≥ 1%) |
Add novel data from the 1,000 Genomes Project, covering minor allele frequencies to down to 1% |
| HumanOmni2.5-8 | 8/1,067* | ~2.5 million | 1000 Genomes Project Pilot (MAF > 2.5%) | Leverage Industry-Best Genomic Coverage with Newly Discovered Common and Rare Variants from the 1000 Genomes Project |
| HumanOmni1S | 8/960† | ~ 1.1 million | 1000 Genomes Project Pilot (MAF > 2.5%) | Add novel data from the first releases of the 1,000 Genomes Project, covering low minor allele frequencies to ~2.5% |
| HumanOmni1-Quad | 4/576† | ~ 1.1 million | HapMap MAF ≥ 5% | Access Optimized Tag SNPs and High-Value Content Including Wellcome Trust Care Consortium Content |
| HumanOmniExpress HumanOmniExpress+ |
12/ ~1,400† 8/960† |
> 700,000 + up to 200,000 custom |
HapMap MAF ≥ 5% | Process thousands of samples per week using optimized tag SNPs at an attractive price |
| Custom BeadChip | Sample Throughput | Attempted Bead Types | Content Description |
|---|---|---|---|
| iSelect | Up to 288 samples/day** |
|
Design Your Own Fully Custom Panel With A Guaranteed > 80% Bead Type Success Rate |
*Throughput based on 1 HiScan, 1 Autoloader, 1 Tecan, 5-day work week.
†Throughput based on 1 iScan, 1 Autoloader2, 1 Tecan, 5-day work week.
**Throughput based on 1 iScan, 1 Autoloader2, 1 Tecan, 8-hour work day.
Infinium Overview
Omni microarrays are built on the powerful Infinium whole-genome genotyping assay. This proven assay chemistry produces unrivaled data quality, superior call rates, and the most consistent reproducibility. The Infinium assay protocol allows for single tube sample preparation without PCR or ligation steps, significantly reducing labor and sample handling errors. The assay can be scaled to unlimited levels of multiplexing without compromising data quality, unlike many alternative PCR-dependent assays.
The assay interrogates genomic markers though a two-step detection process. Carefully designed 50-mer probes selectively hybridize to the loci of interest, stopping one base before the interrogated marker. Allele specificity is conferred by enzymatic single-base extension to incorporate a labeled nucleotide. Subsequent dual-color florescent staining allows the labeled nucleotide to be detected by Illumina’s HiScan or iScan imaging system, which identifies both color and signal intensity. For polymorphic loci, the two color signals are used to indicate the genotype. The signal intensity data can be used to reliably quantify gene copy number variants.
Discover the technology:Watch the Infinium Arrays animation.
GenomeStudio Data Analysis Software
Visualize and analyze data generated by all of Illumina's platforms using the GenomeStudio Data Analysis Software. This powerful informatics solution supports analysis of microarray-based data generated by the HiScanSQ System, iScan System, and BeadXpress Reader. Performance-optimized tools and a user-friendly graphical interface allow you to quickly and easily convert data into meaningful results.
Beeline Software
Beeline Software provides a direct path to project creation and sample management for large array experiments. The time required for data analysis is reduced by flexible allele-calling and data filtering prior to entry into GenomeStudio Data Analysis Software. Windows-based Beeline software works in conjunction with GenomeStudio software to support the analysis of data generated by Infinium and GoldenGate BeadChips.
Product Data Sheets
Genotyping Tech Notes
- Empowering GWAS for a New Era of Discovery
- Genotyping Rare Variants
- Genotype Imputation Enables Powerful Combined Analyses of Genome-Wide Association Studies
- Imputation Estimates Genotypes at Un-Genotyped Loci
- Infinium Genotyping Data Analysis
- The Power of Intelligent SNP Selection
- Array Analysis Workfows Tech Note
CNV Analysis
At Illumina, our goal is to apply innovative technologies and revolutionary assays to the analysis of genetic variation and function, making studies possible that were not even imaginable just a few years ago. These studies will help make the realization of personalized medicine possible. With such rapid advances in technology taking place, it is mission critical to have solutions that are not only innovative, but flexible, scalable, and complete with industry-leading support and service. As a global company that places high value on collaborative interactions, rapid delivery of solutions, and prioritizing the needs of its customers, we strive to meet this challenge. Illumina's innovative, array-based solutions for DNA, RNA, and protein analysis serve as tools for disease research, drug development, and the development of molecular tests in the clinic.