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Superior data quality and a wide range of read lengths have made the Genome Analyzer the system of choice for a broad range of whole-genome scale applications.

Agilent Technologies SureSelect Target Enrichment System leverages the advantages of this high-throughput system. This highly flexible, automatable, and reliable hybridization-based enrichment method enables researchers to isolate up to 5 Mb of genomic regions for high-throughput sequencing.

Combining SureSelect with the Genome Analyzer offers a flexible and efficient solution for targeted resequencing applications including:

 

• Sequencing genes or regions in very large populations

 

 

• Following up on genomic regions of interest identified in genome-wide association studies

 

 

• Focusing on genes involved in certain pathways

 

 

• Identifying signatures associated with disease prevalence

 

• Discovering rare variants

Developed and validated on the Genome Analyzer, the SureSelect Target Enrichment System provides uniform coverage, high reproducibility, and little or no allele bias. The protocol does not require DNA shearing or concatenation, resulting in fewer reactions and opportunities to introduce errors.

The solution-phase workflow enables automation, further reducing sample preparation time. With high content flexibility and a six-week turnaround time for custom panels, the SureSelect Target Enrichment System offers a rapid and proven solution for targeted resequencing.