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Correlation Engine

An interactive omics knowledge base that analyzes private omics data with highly curated public data to help researchers put their data into biological context.

Overview

Correlation Engine is one of the largest biological databases in the world, providing life science researchers with unprecedented access to vast numbers of high-quality whole-genome analyses and insightful scientific tools. The knowledge base enables novel discoveries by interrogating billions of data points derived from standardized analyses of whole-genome studies.

Correlation Engine offers:

  • A comprehensive platform with a suite of applications to determine biological context, a continually growing library of curated data sets, and support for multiple species and multiomic data sets

  • An easy-to-use graphical user interface to leverage guided workflows, push button applications, and APIs

  • A proprietary algorithm that automates and simplifies correlation analysis, finding comparable insights by scanning private data and thousands of public data sets

Accelerate your journey from omic data to discovery

Quickly correlate and ask questions about your data with Correlation Engine’s 256K curated omics signatures.

Specifications

Instruments MiSeq System, NextSeq 550 System, NextSeq 2000 System, NextSeq 1000 System, MiSeqDx in Research Mode, MiniSeq System, NextSeq 550Dx in Research Mode, NovaSeq X System, NextSeq 500 System, iScan System, NovaSeq 6000 System, NovaSeq X Plus System
Software format Cloud
Technology Microarray, Sequencing

Compliance certifications

Applications

Correlation Engine delivers an easy-to-use interactive genomics analysis platform that puts private data in biological context with highly curated public data. Applications support early-stage research to identify mechanisms of disease, drug targets, and prognostic or predictive biomarkers.

Software product portfolio

1
Lab

Clarity LIMS

A highly customizable laboratory information management system that allows genomics labs to track samples and manage workflows efficiently and securely.

2
Run

BaseSpace Sequence Hub

Data management and simplified bioinformatics for labs getting started and for rapidly scaling next-generation sequencing (NGS) operations.

Local Run Manager

Intuitive on-instrument run setup and monitoring.

3
Analytics

DRAGEN secondary analysis

The Illumina DRAGEN Secondary Analysis provides accurate, comprehensive, and efficient analysis of next-generation sequencing data.

BaseSpace Apps

BaseSpace Sequence Hub offers NGS data analysis apps for common Illumina sequencing methods.

Illumina Connected Analytics

A secure genomic data platform to operationalize informatics and drive scientific insights.

4
Insights

Correlation Engine

An interactive omics knowledgebase that puts private omics data in biological context with highly curated public data.

Emedgene

Enable high-efficiency data interpretation workflows for rare disease genomics and other germline research applications, with the support of explainable AI and user-configured automation.

Key use cases

Biomarker discovery and validation

Identify key biomarkers and discover which genes in signatures provide the best markers for major disease areas, optimal therapeutic targets, and mechanisms of action.

Drug repurposing

Look for inverse correlations to discover gene–disease compound links that indicate a new purpose for a drug.

University-wide research libraries

Enable researchers campus-wide to query and use highly curated public omics data to contextualize their data to accelerate their research projects and generate publications.

Drug safety and toxicogenomics

Leverage public toxicology studies to evaluate compound signatures and use curated studies or the meta-analysis app to uncover overlaps with other known toxicogenomic signatures.

Related applications and methods

NGS for drug development

Illumina provides an innovative portfolio of NGS systems, products, and services for many phases of the drug development pipeline.

Multiomics

Use multiomics profiling to multiply discovery power and better connect genotype to phenotype.

Comprehensive analysis solutions for SARS-CoV-2 surveillance

Accelerate coronavirus detection and identification, perform host response studies, simplify your sample tracking, and contribute to public databases.

Documentation

Product literature
Support documentation

Figures

Correlate across data types

Novel correlations and associations are quickly identified for a given query, revealing data-driven connections between genes, diseases, compounds, tissues, and pathways.

Body Atlas

Body Atlas provides insights about where a gene is expressed and its expression level within that location.

Disease Atlas

Disease Atlas delivers correlations between diseases, traits, and conditions associated with queried data.

Pharmaco Atlas

Pharmaco Atlas aids in the discovery of compounds, genomic and epigenomic responses to compounds, and treatments associated with queried data.

Resources

Variant analysis

Our variant annotation and analysis software tools can help researchers extract and report biological insights from large volumes of genomic data.

Accelerate omics pattern discovery

Explore sophisticated multiomic analysis workflows leveraging Correlation Engine.

 

FAQs

No. Currently Correlation Engine supports only human biology and animal model systems. However, the platform can be used to analyze host response to infection.

Correlation Engine supports RNA expression (RNA-Seq), genotyping/SNP GWAS, DNA protein interaction analysis, somatic mutation analysis, and DNA methylation analysis. 

Correlation Engine combines an interactive and easy-to-use interface and pre-built workflows with a comprehensive set of high-quality curated public data, enabling rapid results so that users can move forward to the next experiment without delay. 

There are over 23,000 studies in Correlation Engine. Studies in Correlation Engine are updated weekly. 

Correlation Engine recognizes most public and standard commercial platform identifiers, including NCBI Gene IDs, gene symbols, NCBI accession numbers, ENSEMBL IDs, RefSeq identifiers, IPI ids, and custom IDs from most Affymetrix, Illumina, Agilent, and GE Healthcare platforms.

Correlation Engine uses proprietary rank-based statistics to compute associations between the data you import and all other experimental data. This allows you to place your experimental results within the context of the world's experiments to validate results, discover novel associations, and design new experiments. It correlates your data with all biogroups, allowing discovery of common features among genes or proteins that comprise your study.

Correlation Engine indexes over 19 million abstracts from PubMed and over 130,000 full-text publications from PubMed Central. For literature searches, Correlation Engine uses several heuristics, including:

  • An extensive ontology with relationships between terms and synonyms and a term hierarchy
  • A customized, domain-specific stop word list and analyzer that emphasizes ontology terms
  • The overall authority of the journal in which the paper was published
  • Date of publication
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Interested in trying Correlation Engine?

Academic researchers with a .edu email account can start a free 30-day trial by registering here. Alternatively, if you are a COVID-19 researcher interested in a free 6-month trial, or a commercial customer interested in a purchase, use the sign-up option below.

Order the NovaSeq X Series

Advanced chemistry, optics, and informatics combine to deliver exceptional speed and data quality, outstanding throughput and scalability.

MiSeq Reagent Kit v3

Optimized reagent kit that provides increased cluster density and read length, improving sequencing quality scores compared to earlier versions.

TruSight Oncology 500

Enable CGP with a large pan-cancer panel covering all major variant classes plus gene signatures (TMB, MSI, and HRD) from FFPE tissue.

Illumina DNA Prep

A fast, integrated workflow for preparing libraries for use in a wide range of sequencing applications.

Illumina Connected Analytics Ordering

Operationalize informatics and drive scientific insights with Illumina Connected Analytics. Contact us for information on pricing, subscriptions, and more.

Speak with a specialist

Reach out for information about our products and services, or get answers to questions about our technology.