HumanLinkage V Panel Set

The HumanLinkage V Panel Set is optimized to detect recombination events. Linkage analysis is a powerful approach for mapping the location of disease-causing loci by identifying genetic markers that are co-inherited with the phenotype of interest. The likelihood of a recombination event occurring between two markers is related to the distance between them; markers closest to a disease gene will co-segregate most strongly with the disease phenotype.

The 6,056 HumanLinkage V Panel SNP markers were chosen from highly validated HapMap DNA assays to optimize information content, enabling researchers to extract the greatest amount of data from the least number of markers. Every SNP marker has been robustly validated for physical and genetic map positions, distances, and unique sequence identification.

This GoldenGate HumanLinkage V Panel Set was selected to offer 93% overlap with the Infinium HumanLinkage-12 BeadChip content, allowing researchers to confidently combine genotypes interrogated by both platforms. While the HumanLinkage-12 BeadChip offers a high-throughput solution for most linkage study designs, researchers with formalin-fixed paraffin-embedded (FFPE) and whole-genome amplified samples can use the Linkage V Panel platform.

• The Hunam Linkage V Panel Set can be deployed on 32-, 16-, and 12-sample Universal BeadChips or the 96-sample Universal Array Matrix