HumanOmni1-Quad BeadChip Kits

The completely redesigned four-sample HumanOmni1-Quad BeadChip contains aggressively selected single nucleotide polymorphisms (SNPs) and probes that capture more genomic variation and provide the best power for genome-wide association studies (GWAS) and CNV discovery.

Cutting-edge content includes markers derived from the 1,000 Genomes Project, all three HapMap phases, and recently published studies. Each BeadChip features over one million available assays per sample, containing carefully selected content that delivers dense coverage of the human genome and targets regions known to play a role in human disease.

Intelligent tag SNP selection has been optimized to maintain comprehensive genomic coverage, while reducing tag SNP redundancy. This has enabled the inclusion of additional content carefully chosen to target high-value regions of the genome and new coding variants identified by the 1000 Genomes Project including:

• ABO blood typing SNPs, cSNPs, disease-associated SNPs, eSNPs, SNPs in mRNA splice sites, ADME genes, AIMs, HLA complexes, indels, introns, MHC regions, miRNA binding sites, mitochondrial DNA, PAR, promoter regions, and Y-chromosome

This content includes around 10,000 SNPs targeting four 1Mb regions known to be associated with three or more human diseases; over 31,000 SNPs predicted to be non-synonymous; 40,000 SNPs covering an additional 100 intervals surrounding published peak markers from the NHGRI GWAS database; and the remaining top single-marker associated SNPs from the GWAS database.

• High density markers with a median spacing of 1.2 kb ensure the highest level of resolution for CNV identification in the industry
• A complete optimization of the BeadChip design increases the available complexity, while reducing the amount of required DNA to 200 ng