Infinium II HumanLinkage-12 Panels

Please note that this product has been discontinued. While this product is still currently supported, it is no longer available for purchase.

The Infinium II HumanLinkage-12 Panel includes 6,090 single-nucleotide polymorphism (SNP) markers chosen from validated HapMap DNA assays. The Panel is designed to enable discovery of links between familial genotype and phenotype in both monogenic and polygenic disorders.

The HumanLinkage-12 Panel is optimized to detect recombination events. The likelihood of a recombination event occurring between two markers is related to the distance between them. Markers closest to a disease gene will co-segregate most strongly with the disease phenotype.

Evenly-spaced loci and loci with high minor allele frequencies (MAF) were selected to maximize information content. Compared to other SNP and STR (short tandem repeat) maps, the HumanLinkage-12 panel is superior in uniform spacing and statistical power for detecting linkage to a disease or trait and for defining the linkage interval. SNPs are distributed on every chromosome with an average gap of 441 kb and 0.58 cM.

• With the ability to analyze 12 samples on a single BeadChip, the HumanLinkage-12 Panel offers the industry’s most cost-effective method for studying linkage with the highest information content and data quality
• SNP content on this panel exhibits 93% overlap with the content on the GoldenGate HumanLinkage V Panel Set
• The Panel is powered by the robust Infinium HD Assay, which has a PCR-free protocol and easy workflow