- MyIllumina
- Tools
The Mouse MD Linkage Panel consists of 1,449 SNP loci that have been selected from the Wellcome-CTC Mouse Strain SNP Genotype Set and is optimal for various mapping applications that include characterization of transgenic, congenic and knockout animals, and genetic mapping in advanced intercross mouse lines.
The mouse has been increasingly recognized as an optimal animal for the study of the genetics of complex disease traits. Two Mouse Linkage Panels (Mouse Low Density [LD] Linkage and Mouse Medium Density [MD] Linkage) are available for mouse genetics applications. These single nucleotide polymorphism (SNP) panels offer a low-cost, efficient method for attaining genome-wide genetic data to identify quantitative trait loci (QTLs), map candidate genes, and increase genotyping throughput.
The panel loci were chosen to maximize genetic information across the top ten inbred strains at a higher resolution than the Mouse LD Linkage Panel. SNPs in this panel were chosen to first provide uniform genome distribution at a density of approximately three SNPs per 5 Mb intervals across the genome. At least one SNP per interval was chosen to be informative for crosses involving the C57Bl/6J strain, and the remaining two SNPs were selected based on allele frequency and optimal spacing. On average, at least one SNP in each interval is informative for 75% of pairwise strain combinations.
- The Mouse LD Linkage Panel can be used on 12- and 32-sample Universal BeadChips
- SNP sequences are optimized for Illumina's proven GoldenGate Genotyping Assay protocol
Catalog IDs: GT-18-131
View the product support page for additional technical information ยป
At Illumina, our goal is to apply innovative technologies and revolutionary assays to the analysis of genetic variation and function, making studies possible that were not even imaginable just a few years ago. These studies will help make the realization of personalized medicine possible. With such rapid advances in technology taking place, it is mission critical to have solutions that are not only innovative, but flexible, scalable, and complete with industry-leading support and service. As a global company that places high value on collaborative interactions, rapid delivery of solutions, and prioritizing the needs of its customers, we strive to meet this challenge. Illumina's innovative, array-based solutions for DNA, RNA, and protein analysis serve as tools for disease research, drug development, and the development of molecular tests in the clinic.