Featured Publications

Featured Publication

Composition of the gut microbiota modulates the severity of malaria


Plasmodium infections cause > 200 million cases of malaria and ~ 1 million deaths annually. Using a mouse model and bacterial 16S rRNA sequencing on the MiSeq System, researchers found that certain strains of host gut microbes conferred resistance to Plasmodium infection, indicating a new potential avenue of therapy.

Read more at PubMed »

 
 
Composition of the gut microbiota modulates the severity of malaria
 
 
Worldwide patterns of genomic variation and admixture in gray wolves
 
 
Evaluation of microbial population and functional genes during bioremediation of petroleum-contaminated soil
 
 
Visualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testes
 
 

Composition of the gut microbiota modulates the severity of malaria

Plasmodium infections cause > 200 million cases of malaria and ~ 1 million deaths annually. Using a mouse model and bacterial 16S rRNA sequencing on the MiSeq System, researchers found that certain strains of host gut microbes conferred resistance to Plasmodium infection, indicating a new potential avenue of therapy.

Read more at PubMed »

Villarino NF, LeClair GR, Denny JE, et al. Composition of the gut microbiota modulates the severity of malaria - PNAS

Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse

Researchers used Illumina array technology to perform expression profiling of a mouse model with increased circulating estrogen/androgen ratio. These mice had significantly altered expression of genes related to liver lipid metabolism linked to changes in phospholipid (PL) levels in blood plasma. This altered plasma PL profile is linked to diseases such as liver cancer and diabetes.

Read more at PubMed »

Vehmas AP, Adam M, Laajala TD, et al. Liver lipid metabolism is altered by increased circulating estrogen to androgen ratio in male mouse - J Proteomics

Worldwide patterns of genomic variation and admixture in gray wolves

Though known to be a descendant of the gray wolf, the specific region of origin of the domestic dog is still controversial. Researchers used the HiSeq 2000 System to assemble a data set of full genome sequences for 24 wolves from around the globe and 7 dogs. Analysis revealed that dogs diverged from an extinct Old World (Eurasian) wolf population.

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Fan Z, Silva P, Gronau I, et al.Worldwide patterns of genomic variation and admixture in gray wolves - Genome Res

Evaluation of microbial population and functional genes during the bioremediation of petroleum-contaminated soil as an effective monitoring approach

Researchers used 16S rRNA sequencing on the MiSeq System to profile the diverse microbial community responsible for degradation of petroleum hydrocarbons into nontoxic compounds at 4 bioremediation sites. They found that Gram-negative strains of bacteria were prevalent and critical for success. 16S rRNA sequencing can be used to monitor microbial populations and guide efforts to enhance the bioremediation process.

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Shahi A, Aydin S, Ince B, and Ince O.Evaluation of microbial population and functional genes during the bioremediation of petroleum-contaminated soil as an effective monitoring approach - Ecotoxicol Environ Saf

The impact of oil spill to lung health-Insights from an RNA-seq study of human airway epithelial cells

Researchers performed RNA-Seq on human airway epithelial cells treated with oil, dispersants, and oil-dispersant mixtures. They found strong effects on gene expression from oil or dispersants alone, and synergistic effects in combination. The observed expression profiles correspond to pathological features common in lung diseases such as asthma and cystic fibrosis.

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Liu YZ. Roy-Engel AM, Baddoo MC, et al.The impact of oil spill to lung health-Insights from an RNA-seq study of human airway epithelial cells - Gene

Visualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testes

Using microdissection of seminiferous tubules and Illumina sequencing, researchers found new gain-of-function mutations in the male germline. These de novo point mutations occurred in genes involved in growth factor signaling and RAS oncogenes. Such “paternal age effect” mutations have known associations with congenital or perinatal lethal disorders and cancers.

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Mather GJ, McGowan SJ, Giannoulatou E, et al.Visualizing the origins of selfish de novo mutations in individual seminiferous tubules of human testes - PNAS

Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice

Researchers characterized a novel probiotic mixture that prevents tumor growth in hepatocellular carcinoma mouse models. Shotgun-metagenome sequencing revealed that the mechanism of tumor suppression is via modulation of the gut microbiota toward strains that secrete antiinflammatory metabolites. This prevents differentiation of intestinal immune cells to proinflammatory fates that promote tumor growth.

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Li J, Sung CY, Lee N, et al.Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice - PNAS