Featured Publications

Featured Publication

Expression of olfactory signaling genes in the eye


To investigate how the outer eye interacts with the environment, researchers sequenced the mouse cornea transcriptome. Analysis revealed the expression of several olfactory receptors in the cornea. Results indicate that the human homologs of these olfactory genes might play a role in chemical sensing and signaling in eye tissue.

Read more at PubMed »
View Video: What Eyes & Nose Have in Common »

 
 
Expression of olfactory signaling genes in the eye
 
 
Microbial biogeography of wine grapes is conditioned by cultivar, vintage, and climate
 
 
A missense mutation in DCDC2 causes human recessive deafness DFNB66
 
 
Core and region-enriched networks of behaviorally regulated genes and the singing genome
 
 

Expression of olfactory signaling genes in the eye

To investigate how the outer eye interacts with the environment, researchers sequenced the mouse cornea transcriptome. Analysis revealed the expression of several olfactory receptors in the cornea. Results indicate that the human homologs of these olfactory genes might play a role in chemical sensing and signaling in eye tissue.

Read more at PubMed »

Pronin A, Levay K, Velmeshev D, Faghihi M, Shestopalov VI, Slepak VZ Expression of olfactory signaling genes in the eye - PLoS One

Microbial biogeography of wine grapes is conditioned by cultivar, vintage, and climate

Researchers used the MiSeq System to study the microbial biogeography of wine grapes. 16S rRNA sequencing revealed that regional, site-specific, and varietal factors shape the microbial communities on wine grapes and are correlated to the vineyard environment. The study suggests that climate affects microbial inhabitation patterns, influencing wine quality and taste.

Read more at PubMed »

Bokulich NA, Thorngate JH, Richardson PM, Mills DA Microbial biogeography of wine grapes is conditioned by cultivar, vintage, and climate - Proceedings of the National Academy of Sciences USA

A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation

Using whole-exome sequencing, scientists identified a homozygous mutation in DCDC2 associated with profound congenital deafness. They investigated the effect of this variant in a rat model and found that the gene is involved in hair structure and function in the inner ear, suggesting a possible disease mechanism.

Read more at PubMed »

Grati M, Chakchouk I, Ma Q, et al. A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation - Human Molecular Genetics

Core and region-enriched networks of behaviorally regulated genes and the singing genome

Songbirds are a common model used to study the molecular mechanisms of human speech. Using microarrays and sequencing, researchers analyzed singing-related gene expression in zebra finches. They found that singing is regulated by region-specific transcription factors and histone-regulated gene activation in the brain.

Read more at PubMed »

Whitney O, Pfenning AR, Howard JT, et al. Core and region-enriched networks of behaviorally regulated genes and the singing genome - Science

Mitochondrial genome sequencing and development of genetic markers for the detection of DNA of invasive bighead and silver carp (Hypophthalmichthys nobilis and H. molitrix) in environmental water samples from the United States

Using the MiSeq System, researchers sequenced mtDNA of invasive bighead and silver carp to develop species-specific genetic markers. They used the markers to detect the presence of these fish in water samples. This study offers new tools for monitoring invasive species that threaten aquatic ecosystems.

Read more at PubMed »

Farrington HL, Edwards CE, Guan X, Carr MR, Baerwaldt K, Lance RF Mitochondrial genome sequencing and development of genetic markers for the detection of DNA of invasive bighead and silver carp (Hypophthalmichthys nobilis and H. molitrix) in environmental water samples from the United States - PLoS One

Transmission of methicillin-resistant Staphylococcus aureus infection through solid organ transplantation: confirmation via whole genome sequencing

Researchers at the CDC used the MiSeq System to track MRSA infections that developed after organ transplantation. Whole-genome sequencing of bacterial isolates confirmed transmission from the organ donor, suggesting that the standard course of antibiotics might not prevent donor-derived infection.

Read more at PubMed »

Wendt JM, Kaul D, Limbago BM, et al. Transmission of methicillin-resistant Staphylococcus aureus infection through solid organ transplantation: confirmation via whole genome sequencing - American Journal of Transplantation

The gut microbiota of rural Papua New Guineans: composition, diversity patterns, and ecological processes

Using the MiSeq System, investigators compared the gut microbiota of adults from Papua New Guinea and the United States. Papua New Guineans showed greater microbial diversity, different abundance profiles, and unique lineages. Findings suggest that the microbiomes of western societies have limited bacterial dispersal.

Read more at PubMed »

Martínez I, Stegen JC, Maldonado-Gómez MX, et al. The gut microbiota of rural Papua New Guineans: composition, diversity patterns, and ecological processes - Cell Reports

The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation

Researchers sequenced, assembled, and annotated the grass carp genome. Phylogenetic analysis indicated that activation of steroid biosynthesis via the mevalonate pathway is associated with adaptation from a carnivorous to an herbivorous diet. This draft genome might aid genomic breeding efforts for global aquaculture.

Read more at PubMed »

Wang Y, Lu Y, Zhang Y, et al. The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation - Nature Genetics