Increasing understanding of immune-related complex diseases

Immunology Research

Illumina technology can advance immunology research by helping elucidate immune cell function and signaling. Immune cells work to protect the body from foreign invaders including viruses, bacteria, and parasites. Mutations and environmental factors can cause the immune system to malfunction and attack the body it is meant to protect. Many immune disorders are classified as complex diseases since they are influenced by both genetics and the environment.

Complex autoimmune disorders include lupus, rheumatoid arthritis, inflammatory bowel disease, and others. The cause and progression of many of these diseases are still not understood.

Array and next-generation sequencing (NGS) solutions from Illumina can provide immunology researchers with detailed insight into the potential genetic causes and functional consequences of variation.

TruSight HLA: Sequence 11 HLA loci for high-resolution, phase-resolved haplotyping in one assay.

Infinium ImmunoArray-24 v2 BeadChip Kit: Perform research to evaluate autoimmune disorder and immune function–associated genetic variants on a single array.

Immunology Research Review

View publication summaries showing how researchers use NGS to map the human immune response at high resolution.

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Understanding Tumor Immunogenicity

NGS can help researchers identify mutations that enable tumors to evade the immune response, as well as neoantigens that can boost T cell-mediated immunity.

Learn More About Immuno-Oncology Research

T Cell-Mediated Immunity
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Driving IBD Discovery with Integrative Genomics
Driving IBD Discovery with Integrative Genomics

Dr Carl Anderson discusses integrated genomic research approaches in inflammatory bowel disease (IBD) research.

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NGS and Arrays to Profile Genomic Regulation
NGS and Arrays to Profile Genomic Regulation

Gain a better understanding of genomic techniques used to profile the transcriptome and epigenome in complex, multifactorial disease.

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Human Macrophage Activation with Transcriptome Profiling
Human Macrophage Activation with Transcriptome Profiling

Gain insight into human macrophages’ global reprogramming on the transcriptional level.

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Autoimmune Disease Mechanisms
Autoimmune Disease Mechanisms

See how researchers use NGS to study T cell receptor diversity and autoimmune diseases, and unravel other disease mechanisms.

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Cancer and Immune System Research Review
Cancer and Immunology Research Review

Read publication reviews showing the utility of NGS for immunology-related cancer research.

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HLA Genetics in Autoimmune Disease
HLA Genetics in Autoimmune Disease

Researchers query the genome with NGS and high-throughput genotyping to identify novel risk loci for immune-mediated disease.

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NGS to Survey Chromatin Landscape
NGS to Survey Chromatin Landscape

New epigenetics method maps open chromatin regions to give a multidimensional portrait of gene regulation in complex disease.

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Driving ALS Discovery with Integrative Genomics
Driving ALS Discovery with Integrative Genomics

Jan Veldink, PhD shares how integrative genomics helped drive his ALS research, leading to the discovery that NEK1 is an ALS gene.

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TruSeq RNA Access Kit

A reproducible, economical method for sequencing coding RNA, including FFPE samples. View Kit.

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NextSeq Series

Flexible desktop sequencing systems that support various applications, from targeted panels to whole-genome sequencing. Learn More.

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BaseSpace Platform

The Illumina genomics computing environment for NGS data analysis and management, so labs can analyze, archive, and share data easily. Learn More.

See All Data Analysis Tools