Making sense of neurological complex diseases

Neuroscience Research

Neurological complex diseases include Alzheimer’s and Parkinson’s disease, neuromuscular disorders such as amyotrophic lateral sclerosis (ALS), and psychiatric conditions including depressive disorders and schizophrenia which are all the result of multifactorial interactions.

It is only recently through next-generation sequencing (NGS) studies that the full genomic complexity of neurological diseases is being revealed. The interplay between heritable and nonheritable mutations, epigenetics, and other factors requires NGS-level analyses to increase our understanding. Illumina has the array and NGS tools needed to make genomic neuroscience research possible.

TruSeq Targeted RNA Expression Neurodegeneration Panel: This assay offers an RNA sequencing solution for studying neurodegenerative and neurotoxic pathways such as those implicated in Alzheimer’s disease.

Infinium PsychArray BeadChip: This array enables researchers to evaluate genetic variants associated with common psychiatric disorders.

NGS in Schizophrenia Research

See how researchers are using targeted RNA sequencing to study gene expression alterations associated with schizophrenia.

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Neuroscience Research Review
Neuroscience Research Review

View a summary of recent publications that use NGS to understand neurological disorders.

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Genetic Studies of Memory
Genetic Studies of Memory

Learn how researchers are using NGS to understand the neurological variables that affect learning and memory.

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From Genotype to Phenotype
From Genotype to Phenotype

Dr. Lachlan Jolly discusses insights on gene function in cell models of brain development.

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Mapping Neural Diversity with Single-Cell mRNA-Seq
Mapping Neural Diversity with Single-Cell mRNA-Seq

The ability to analyze gene expression signatures from individual cells is transforming the way neurons are classified.

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NGS to Study Genetics of Brain Development
NGS to Study Genetics of Brain Development

Researchers apply functional genomic methods to identify the role of gene variants in intellectual disability.

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Genomic Architecture of Neurodegenerative Disease
Genomic Architecture of Neurodegenerative Disease

High-throughput genomics enables insights about genes and biological pathways associated with diseases like Alzheimer’s and Parkinson’s.

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High-Throughput Detection of Somatic Mosaicism
High-Throughput Detection of Somatic Mosaicism

Targeted resequencing is enabling a systematic high-throughput approach to identify rare mosaic mutations in brain malformations.

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Driving ALS Discovery with Integrative Genomics
Driving ALS Discovery with Integrative Genomics

Jan Veldink, PhD shares how integrative genomics helped drive his ALS research, leading to the discovery that NEK1 is an ALS gene.

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