Making sense of neurological complex diseases

Neuroscience Research

Neurological complex diseases include Alzheimer’s and Parkinson’s disease, neuromuscular disorders such as amyotrophic lateral sclerosis (ALS), and psychiatric conditions including depressive disorders and schizophrenia which are all the result of multifactorial interactions.

It is only recently through next-generation sequencing (NGS) studies that the full genomic complexity of neurological diseases is being revealed. The interplay between heritable and nonheritable mutations, epigenetics, and other factors requires NGS-level analyses to increase our understanding. Illumina has the array and NGS tools needed to make genomic neuroscience research possible.

Infinium PsychArray BeadChip: This array enables researchers to evaluate genetic variants associated with common psychiatric disorders.

Kailos TargetRich PGxComplete: This enrichment-based targeted sequencing research panel covers 43 genes associated with responses to ~100 medications.

Kailos Blue Analytics provide sequencing quality assessment, alignment, and variant calling in output formats suitable for use with a variety of reporting solutions.

NGS for Variant Discovery in Neuroscience Research

Dr. Franco Taroni uses multigene sequencing panels to uncover novel variants associated with metabolic and neurological disorders.

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Neuroscience Research Review
Neuroscience Research Review

View a summary of recent publications that use NGS to understand neurological disorders.

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Genetic Studies of Memory
Genetic Studies of Memory

Learn how researchers are using NGS to understand the neurological variables that affect learning and memory.

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From Genotype to Phenotype
From Genotype to Phenotype

Dr. Lachlan Jolly discusses insights on gene function in cell models of brain development.

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Mapping Neural Diversity with Single-Cell mRNA-Seq
Mapping Neural Diversity with Single-Cell mRNA-Seq

The ability to analyze gene expression signatures from individual cells is transforming the way neurons are classified.

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NGS to Study Genetics of Brain Development
NGS to Study Genetics of Brain Development

Researchers apply functional genomic methods to identify the role of gene variants in intellectual disability.

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Genomic Architecture of Neurodegenerative Disease
Genomic Architecture of Neurodegenerative Disease

High-throughput genomics enables insights about genes and biological pathways associated with diseases like Alzheimer’s and Parkinson’s.

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Integrating Genomic Data for Neurobiology Research
Integrating Genomic Data for Neurobiology Research

Jonathan Mill, PhD and his team are leading the way toward a better understanding of neuropsychiatric diseases.

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Driving ALS Discovery with Integrative Genomics
Driving ALS Discovery with Integrative Genomics

Jan Veldink, PhD shares how integrative genomics helped drive his ALS research, leading to the discovery that NEK1 is an ALS gene.

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