Efforts to move from Exomes to Whole Genomes in Oncology Research

Efforts to move from Exomes to Whole Genomes in Oncology Research

Professor Christof von Kalle
Topic: Cancer Genomics

Hear Prof. Christof von Kalle describe his efforts to move from exome to whole genome, challenges and successes so far and the vision of cancer care at NCT and DKFZ. Advances in high-throughput sequencing lead to increasingly accurate information about somatic alterations in cancer genomes at decreasing costs. Whole genome sequencing (WGS) provides a more complete picture considering structural variants and copy numbers and is a comprehensive way to detect non-coding mutations, including promoter enhancers. Thus, WGS may hold the key to drive precision oncology and individualized treatment decision to the next level.



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