Lungs, Germs, and Metabolites: A Cystic Fibrosis Story

Lungs, Germs, and Metabolites: A Cystic Fibrosis Story

Topic: None

Dynamic microbial and viral communities constantly inhabit our bodies, encoding the majority of the unique genes that alter processes throughout our bodies and our lives. Persistent and unique viral and microbial communities are associated with every human, and they are powerful indicators of health and disease. Metagenomics, metabolomics, microbiology and ecological statistics can be used to answer questions about how microbes and viruses affect human health.

Next-Generation sequencing has enabled a torrent of recent discoveries about the composition and activity of human-associated microbial communities. In this webinar, we present recent work enabled by microbial DNA sequencing of human samples from healthy people and cystic fibrosis (CF) patients. Earlier and more specific diagnosis and treatment of periods of worsened symptoms known as pulmonary exacerbations in CF may be possible using paired metabolomic and metagenomic approaches to uncover biomarkers of disease state.

 


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