Genome sequencing for clinical use has the potential to reduce diagnostic odysseys, refine diagnostic evaluations, increase our understanding of prognoses, and improve patient care. In order to establish whole-genome sequencing as another tool at the physician's disposal, several components must be carefully developed and evaluated. Among these are physician and patient support, informed consent, secure data management, and, critically, the analytical quality of the data generated for clinical interpretation. As we move towards an era of genomic testing and increase our knowledge of the genome, analytical validity becomes increasingly important. In this webinar we discuss the lessons and best practices learned by the CLIA-certified, CAP-accredited Illumina Clinical Services Laboratory.