ForenSeq DNA Signature Prep Kit

Access a wider range of informative SNPs with a single kit. Includes all reagents to prepare sequencing libraries from forensic DNA samples. Read More...
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ForenSeq DNA Signature Prep Kit

TG-450-1001

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ForenSeq Index Adapter Fixture

FC-451-1001

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Product Highlights

The ForenSeq DNA Signature Prep Kit is part of a complete, fully validated DNA-to-data solution designed for forensic genomics applications. It includes all reagents to prepare next-generation sequencing (NGS) libraries from forensic DNA samples.

Achieve high resolution and exceptional accuracy from as little as 1 ng of DNA—Even with complex mixtures or degraded DNA. This kit allows labs to:

  • Perform multiplexing and rapid sample processing
  • Access a wider range of informative single-nucleotide polymorphisms (SNPs) with a single kit
  • Analyze challenging samples
Multiplexing and rapid sample processing

The ForenSeq DNA Signature Prep Kit supports preparation of up to 96 libraries simultaneously using a simple plate-based format and standard lab equipment. Targeted primer mixes enable analysis of autosomal, Y- and X-chromosome short tandem repeat (STR) targets, and identity-informative SNPs, all in a single reaction.

Optionally, you can include biogeographical ancestry-informative SNPs (aiSNPs) and phenotypic-informative SNPs (piSNPs). This data can be critical in generating investigative leads from “no suspect” cases that have otherwise gone cold.

A wider range of informative SNPs with a single kit

The ForenSeq DNA Signature Prep Kit consolidates all autosomal STR markers currently used around the world for casework and criminal DNA databases. This single, streamlined workflow eliminates the need to run multiple STR tests.

The kit delivers approximately 200 genetic markers in a single test, removing the tradeoffs and risk imposed by technical limitations such as low DNA quantity. It also contains a dense set of identity informative single nucleotide polymorphism (iiSNP) marker sets not routinely available with traditional capillary electrophoresis (CE) methods.

Superior analysis of challenging samples

Cases are often complicated and sometimes unresolved due to the presence of highly degraded DNA, low quality DNA, or complex DNA mixtures. The ForenSeq DNA Signature Prep Kit includes a large number of markers, many of which are highly polymorphic.

These additional markers, coupled with the inherent sensitivity of Illumina chemistry, help detect minor components that might go undetected by conventional STR and CE analysis.

Specifications

Method-Specific Workflow Example

 

Customer Stories

The Future of Forensic Genomics is Here

King’s College London researchers are finding that the MiSeq FGx Forensic Genomics System provides more information-rich data than CE-based forensic DNA testing methods.

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Harnessing NGS Technology to Solve Crimes

Criminalists at the California Department of Justice find that the MiSeq FGx Forensic Genomics System is a significant advancement in DNA profiling technology over traditional CE-based methods.

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Supporting Data and Figures

 

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