Cancer Research Applications
Cancer applications in action
Advancements in research are driving breakthroughs in cancer. With the high-throughput capabilities of NGS to rapidly and accurately obtain large volumes of data, scientists are making discoveries to understand how cancers arise, evolve, and respond to treatments. NGS has made countless contributions to cancer research beyond genomic sequencing alone. Today, NGS allows researchers to understand biological events at the transcriptomic, epigenomic, and proteomic levels for novel applications such as single-cell studies, liquid biopsies, immunotherapies, and more.
Popular cancer research applications
Cancer single-cell analysis
Single-cell sequencing allows researchers to understand drivers of cancer at the DNA, RNA, epigenetic, and protein levels (individually or as multiomic experiments) with single-cell resolution.
Liquid biopsy research
Involves the analysis of genetic material (e.g., cell-free DNA, circulating tumor cells) from bodily fluids (e.g., blood, urine) to detect and monitor cancer-related genetic alterations. Liquid biopsies offer a less invasive alternative to traditional tissue biopsies.
Cancer biomarkers
Cancer biomarkers can offer information about cancer activity and risks. NGS can simultaneously profile hundreds of cancer biomarkers, enabling actionable insights for cancer research.
Immuno-oncology research and tumor microenvironments
Immuno-oncology is an emerging field where NGS plays a significant role in analyzing immunotherapy response factors, discovering biomarkers, and applying genomics for personalized immunotherapy. NGS can efficiently assess the tumor microenvironments for immune marker expression in response to tumor growth, treatments, and more while simultaneously profiling thousands of gene expression targets.
Cancer research methods
Cancer sequencing methods
Learn about NGS-based cancer sequencing methods, which provide more information in less time than single-gene and array-based approaches.
New 2023 Cancer Methods Guide
The Cancer Methods Guide is a 40+ page comprehensive resource covering cancer research topics, methods, solutions, and more.
Cancer research solutions
Cancer research kits and reagents
Find sequencing and microarray kits that enable researchers to analyze genomic alterations in cancer samples.
Cancer whole-genome sequencing
Discover novel features and benefits with whole-genome sequencing for cancer research.
Sequencing platforms
Explore our line of NGS platforms. View benchtop and production-scale NGS sequencer comparison tables and find tools designed to help you choose the right platform for your needs.
Additional resources
Cancer research overview
Get an overview of cancer research and explore methods for a multiomic approach to study this complex disease.
Redefining NGS in cancer research
In this webinar, experts cover essential background topics in NGS, achievements, challenges, and how an integrated multiomics approach can be used in cancer diagnosis and treatment.
Cancer research feature articles
Read featured articles on cancer research from scientists worldwide covering a broad range of topics.
Interested in receiving newsletters, case studies, and information on cancer research?
References
- Donoghue MTA, Schram AM, Hyman DM, Taylor BS. Discovery through clinical sequencing in oncology. Nat Cancer. 2020;1(8):774-783. doi:10.1038/s43018-020-0100-0
- van Rooij N, van Buuren MM, Philips D, et al. Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma. J Clin Oncol. 2013;31(32):e439-e442. doi:10.1200/JCO.2012.47.7521
- Calis JJ, Rosenberg BR. Characterizing immune repertoires by high throughput sequencing: strategies and applications. Trends Immunol. 2014;35(12):581-590. doi:10.1016/j. it.2014.09.004
- Emerson RO, Sherwood AM, Rieder MJ, et al. High-throughput sequencing of T-cell receptors reveals a homogeneous repertoire of tumour-infiltrating lymphocytes in ovarian cancer. J Pathol. 2013;231(4):433-440. doi:10.1002/path.4260