Featured Publications

Featured Publication

Psychiatric gene discoveries shape evidence on ADHD's biology.


Despite findings that attention-deficit hyperactivity disorder (ADHD) is highly heritable, little is known about its pathophysiology. Researchers analyzed biologically active pathways in ADHD and control copy number variant (CNV) data sets. They found enrichment of multiple genes in ADHD data sets previously associated with schizophrenia and autism, indicative of possible common pathogenic mechanisms.

Read more at PubMed »

 
 
Psychiatric gene discoveries shape evidence on ADHD's biology.
 
 
MicroRNAs in honey bee caste determination.
 
 
Western diet enhances susceptibility to intestinal infection and inflammation.
 
 
Personalized nutrition by prediction of glycemic responses.
 
 

Serum miRNA panel as potential biomarkers for chronic hepatitis B with persistently normal alanine aminotransferase.

Approximately 30% of patients with hepatitis have normal blood serum levels of alanine aminotransferase (ALT), making this marker insufficient for hepatitis diagnosis and monitoring. By sequencing circulating miRNAs, researchers discovered novel miRNA biomarkers and constructed accurate miRNA panels with clinical value for diagnosing hepatitis in all patients.

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Tan Y, Ge G, Pan T, et al. Serum miRNA panel as potential biomarkers for chronic hepatitis B with persistently normal alanine aminotransferase. - Clin Chim Acta

Genome-wide patterns of selection in 230 ancient Eurasians.

The advent of farming in Europe ~8500 years ago shaped genetic changes in ancient humans enabling them to adapt to new diets, environments, and pathogens. Though indirect evidence of these adaptions persists in the genomes of contemporary people, it is difficult to analyze. Advances in ancient DNA sampling allowed NGS analysis of Eurasians from 6500 to 300 BC. Researchers detected natural selection at loci associated with diet, immunity, and height.

Read more at PubMed »

Mathieson I, Lazaridis I, Rohland N, et al. Genome-wide patterns of selection in 230 ancient Eurasians. - Nature

Psychiatric gene discoveries shape evidence on ADHD's biology.

Despite findings that attention-deficit hyperactivity disorder (ADHD) is highly heritable, little is known about its pathophysiology. Researchers analyzed biologically active pathways in ADHD and control copy number variant (CNV) data sets. They found enrichment of multiple genes in ADHD data sets previously associated with schizophrenia and autism, indicative of possible common pathogenic mechanisms.

Read more at PubMed »

Thapar A, Martin J, Mick E, et al. Psychiatric gene discoveries shape evidence on ADHD's biology. - Mol Psychiatry

MicroRNAs in honey bee caste determination.

Biological constraints during development cause 3 adult phenotypes in honeybees (Apis mellifera): the queen, female workers, and male drones. Researchers analyzed microRNA and transcriptional profiles at determinant stages of larval development. They found significant differences between the 3 phenotypes in areas of physio-metabolic pathways and neuronal development.

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Ashby R, Foret S, Searle I, et al. MicroRNAs in honey bee caste determination. - Sci Rep

Western diet induces a shift in microbiota composition enhancing susceptibility to adherent-invasive E. coli infection and intestinal inflammation.

Inflammatory bowel diseases (IBD) are more prevalent in countries with high-fat/high-sugar (HF/HS) diets. Using rRNA sequencing, researchers analyzed mice fed a HF/HS diet compared to a conventional diet. Proinflammatory bacteria replaced protective bacteria in the gut, and levels of antiinflammatory short-chain fatty acids (SCFAs) decreased. SCFA receptors may be a therapeutic target for IBD.

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Agus A, Denizot J, Thevenot J, et al. Western diet induces a shift in microbiota composition enhancing susceptibility to adherent-invasive E. coli infection and intestinal inflammation. - Sci Rep

Personalized nutrition by prediction of glycemic responses.

Researchers studied a cohort of 800 people eating identical meals. They found high variability in postmeal blood glucose response, indicating that universal dietary recommendations may have limited utility. Researchers used NGS of gut microbiota and other metabolic data to create an algorithm that accurately predicts postmeal glucose response, potentially enabling personalized diet recommendations.

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Zeevi D, Korem T, Zmora N, et al. Personalized nutrition by prediction of glycemic responses. - Cell

Domestication selected for deceleration of the circadian clock in cultivated tomato.

The circadian clock is a critical regulator of plant physiology and development. Hypothesizing that plant domestication affects this process, researchers analyzed cultivated tomato species and wild relatives. RNA-Seq analysis confirmed a deceleration of the molecular clock in cultivated varieties, likely a result of human selection for slower circadian rhythms ideal for the growing season.

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Muller NA, Wijnen CL, Srinivasan A, et al. Domestication selected for deceleration of the circadian clock in cultivated tomato. - Nat Genet

The endosymbiotic bacterium Wolbachia selectively kills male hosts by targeting the masculinizing gene.

Wolbachia is a genus of intracellular, parasitic bacterium that infects insects and alters host reproduction to facilitate its own propagation. Wolbachia exhibits male-killing during embryogenesis to enhance production of infected females. RNA-Seq analysis discovered that the mechanism of this process involves inhibition of masculinizing genes and a failure of dosage compensation in males.

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Fukui T, Kawamoto M, Shoji K, et al.The endosymbiotic bacterium Wolbachia selectively kills male hosts by targeting the masculinizing gene. - PLoS Pathog