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Max Read Number  M
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Sequencing Platform Selector

This tool will help you compare next-generation sequencing systems and find the one that’s right for your lab or application.

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Research Use Only Molecular Diagnostics

Cancer Genomics Forensic Genomics Agrigenomics Genetic Disease Microbial Genomics Reproductive Health Population-scale Human WGS Other Area of Interest

DNA Sequencing RNA Sequencing Epigentic Analysis

Large genome (e.g. mammalian, plant) Small genome (e.g., microbial) Targeted – Exome or Large Gene Panels Targeted – Amplicon or Small Gene Panels

RNA Profiling Transcriptome Analysis Small RNA Analysis

ChIP-Seq Methylation Sequencing

MiSeqDx

Next-generation sequencing (NGS) technology can provide a broad view of the human genome, helping us discover and apply relevant genomic information to human health. Ultimately, this may lead to more accurate diagnosis, prognosis, and therapeutic selection. Clinical laboratories can take advantage of the benefits of NGS with the FDA-cleared MiSeqDx system.

At the heart of the system is the FDA-cleared MiSeqDx instrument, stringently validated for design and performance. Two IVD assays and one IVD kit are currently available for use on the MiSeqDx instrument:

  • The MiSeqDx Universal Kit allows users to develop their own NGS laboratory tests, expanding their lab offerings to meet ever-evolving needs
  • The MiSeqDx Cystic Fibrosis 139-Variant Assay detects 139 clinically relevant and functionally verified CFTR variants
  • The MiSeqDx Cystic Fibrosis Clinical Sequencing Assay detects mutations within the protein coding regions and intron/exon boundaries of CFTR

MiSeq FGx

The MiSeq FGx Forensic Genomics System is the first fully validated sequencing system designed for use in forensic genomics applications. The complete sample-to-answer system uses dedicated library preparation kits, customized instrument control software, and an analytical software package to support the reliable analysis of both routine and challenging forensic samples.

The MiSeq FGx System workflow is easy-to-use, automated, and fast:

  • Compact, all-in-one platform incorporates cluster generation, paired-end fluidics, and SBS chemistry
  • Intuitive touch screen interface makes for simple instrument operation
  • Plug-and-play reagents with RFID tracking make for added speed and convenience

HiSeq X Ten & HiSeq X Five

The HiSeq X Series delivers the first truly affordable human genome—on a massive scale. Scientists, institutions, and nations are now empowered to create a comprehensive catalog of human variation, forge population-based references, drive far-reaching discoveries, and advance our understanding of human biology and genetic disease.

The HiSeq X Ten and HiSeq X Five Systems take sequencing to the next level:

  • Designed and optimized for population- and production-scale human whole-genome sequencing
  • Advanced patterned flow cell technology generates massive throughput
  • The $1000 genome is now a reality with the HiSeq X Ten System
  HiSeq X Series
 
 

HiSeq X Five
 

HiSeq X Ten
Output Range 900 - 1800 Gb 900 - 1800 Gb
Maximum Read Length 2 x 150 bp 2 x 150 bp
Reads per Run 3 - 6 billion 3 - 6 billion
Run Time <3 days <3 days
Key Methods Production-scale human whole-genome sequencing.

For Research Use Only. Not for use in diagnostic procedures.
Population-scale human whole-genome sequencing.

For Research Use Only. Not for use in diagnostic procedures.
Price per Sample* Higher Lower
Instrument Price* Lower Higher
Samples per Run* 8 - 16 8 - 16
Specifications Sheet Download Download
  Learn More Learn More
*Assumptions Based on 30X coverage of a human genome, assumes minimum of 100Gb per genome. Sample number will vary for other species based on relative genome size.


Specifications shown for an individual HiSeq X Sequencing System. HiSeq X is only available as part of the HiSeq X Five or HiSeq X Ten.

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Focused power.

 
MiSeq Series

Flexible power.

 
NextSeq Series

Production power.

 
HiSeq Series
Key Methods Small genome, amplicon, and targeted gene panel sequencing. Everyday genome, exome, transcriptome sequencing, and more. Production-scale genome, exome, transcriptome sequencing, and more.
  MiSeq Series
NextSeq Series
HiSeq Series
 
 

MiSeq
 

MiSeqDx
 

MiSeq FGx
 

NextSeq 500
 

HiSeq 2500
 

HiSeq 3000
 

HiSeq 4000
Output Range 0.5 - 15 Gb 0.5 - 15 Gb 0.5 - 15 Gb 20 - 120 Gb 10 - 1000 Gb 125 - 750 Gb 125 - 1500 Gb
Maximum Read Length 2 x 300 bp 2 x 300 bp 2 x 300 bp 2 x 150 bp 2 x 150 bp 2 x 150 bp 2 x 150 bp
Reads per Run 15 million 15 million 15 million 130 - 400 million 300 million - 4 billion 2.5 billion 2.5 - 5 billion
Run Time 4hr - 55 hr 4 - 55 hr 4- 55 hr 11 hr - 29 hr 7 hr - 6 days <1 - 3.5 days <1 - 3.5 days
Key Methods Small genome, amplicon, & targeted gene panel sequencing.

For Research Use Only.  Not for use in diagnostic procedures.
Small genome, amplicon, & targeted gene panel sequencing.

In Vitro Diagnostic applications.
Small genome, amplicon, & targeted gene panel sequencing.

For Research, Forensic, and Paternity Use Only.
Exome, transcriptome, & whole-genome sequencing.

For Research Use Only. Not for use in diagnostic procedures.
Exome, transcriptome, & whole-genome sequencing.

For Research Use Only. Not for use in diagnostic procedures.
Exome, transcriptome, & whole-genome sequencing.

For Research Use Only. Not for use in diagnostic procedures.
Exome, transcriptome, & whole-genome sequencing.

For Research Use Only. Not for use in diagnostic procedures.
Price per Sample* 6 6 6 5 4 3 3
Instrument Price* 1 2 1 2 3 4 5
Samples per Run* - N/A 1 - 96 1 1 - 8 6 6 - 12
Samples per Run* 1 - 96 N/A 1 - 96 96 96 - 1536 768 768 - 1536
Samples per Run* 1 N/A 1 - 96 3 - 12 12 - 150 90 90 - 180
Samples per Run* 3 N/A 1 - 96 15 - 48 36 - 72 N/A N/A
Samples per Run* 1 - 2 N/A 1 - 96 12 - 36 24 - 396 250 250 - 500
Samples per Run* - N/A 1 - 96 2 - 8 12 - 80 50 50 - 100
Samples per Run* 1 - 5 N/A 1 - 96 25 - 80 60 - 792 N/A N/A
Samples per Run* 1 N/A 1 - 96 8 - 24 20 - 264 160 160 - 320
Samples per Run* - N/A 1 - 96 1 1 - 10 Not currently supported Not currently supported
Specifications Sheet Download Download Download Download Download Download Download
  Learn More Learn More Learn More Learn More Learn More Learn More Learn More
*Assumptions Based on 30X coverage of a human genome, assumes minimum of 100Gb per genome. Sample number will vary for other species based on relative genome size.
*Assumptions Based on 30x or greater coverage of a 5Mb microbial genome.
*Assumptions Based on 4Gb per sample at 2x75 bp.
*Assumptions Based on TruSight One Sequencing Panel.
*Assumptions 10M reads per sample.
*Assumptions 50M reads per sample.
*Assumptions 5M reads per sample.
*Assumptions 15M reads per sample for identification of transcription factor binding. Additional reads required for histone marks.
*Assumptions 30X coverage.


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  • Illumina Next-Generation Sequencing Platforms

    Illumina offers innovative next-generation sequencing (NGS) platforms that deliver industry-leading data quality and accuracy, at an unparalleled scale. With flexible throughput and simple, streamlined workflows, our sequencing platforms are transforming the field of genomics.

    Illumina technology empowers more and more NGS users every day. NGS has transformed the genomics community to include clinical, agrigenomics, and forensic genomics researchers, and continues to enable advances in cancer genomics, microbiology, and other areas.

    NGS Platforms with Proven Performance

    Illumina NGS platforms have been adopted by leading institutions around the world, both big and small, and are the production platform for all major genome centers. More bases have been sequenced using Illumina chemistry than all other next-generation sequencing platforms combined.

    Our track record of relentless innovation is evident in the number and breadth of research publications. Illumina NGS platforms enable the broadest suite of sequencing applications, including the first FDA-cleared NGS system for diagnostic applications.

    Our newly expanded sequencing platform portfolio will transform your research and enable new discoveries. Illumina systems deliver what you need, when you need it.

    Each platform delivers industry-leading data quality and performance, with flexible throughput and simple, streamlined workflows—for every kind of researcher, for every scale of study.

  • Simple, Fully Integrated Sequencing Solutions

    Rapid, high-quality NGS library preparation is a key element of the integrated sequencing platform workflows that Illumina offers. The easy-to-use library preparation and enrichment products enable sequencing of a wide variety of samples—including challenging, low-input, and even FFPE samples.

    Illumina also offers a broad range of intuitive bioinformatics applications for data analysis, alignment, variant calling and more. Sequencing data can be instantly and securely transferred, stored, and analyzed in the BaseSpace genomics computing environment.

    Results are presented in intuitive, easy-to-interpret reports, enabling rapid identification of variants, and the ability to instantly share data with collaborators around the world.

    Illumina users can also access a rich ecosystem of third-party tools for data analysis.

  • Next-Generation Sequencing Platform Innovation is in our DNA

    Illumina has pioneered major advances for NGS platforms in simplicity and flexibility – all while delivering industry-leading performance. Sequencing output has grown a thousand-fold, from less than 1 gigabase to over 1 terabase per run, while the number of reads has increased from millions to billions. Experiments that once required complex workflows now use simple push-button sequencing. Illumina continues to lead the field in sequencing platform innovation and performance.

    Read the sequencing platform portfolio brochure (PDF) to learn more.