Understanding epigenetic modifications and their impact on gene regulation

Powerful solutions for studying heritable changes outside of the DNA sequence

Epigenetics

The epigenome comprises the chemical modifications that shape the physical structure of the genome. It regulates gene expression, enabling select genes to be active at different times during the cell life cycle. Epigenetics play a significant role in growth, development, and disease progression. The epigenome changes in response to diet, stress, and other environmental factors.

Illumina offers a broad portfolio of sequencing- and array-based epigenetic analysis tools that provide robust, simple-to-use, and cost-efficient solutions for studying epigenetic modifications and their impact on gene regulation. By working with leading epigenomics experts, Illumina ensures its solutions meet the field's rapidly evolving needs.

DNA Methylation Analysis

Investigate methylation patterns quantitatively across the genome using sequencing- and array-based techniques.

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DNA-Protein Interaction Analysis

Gain insight into protein and DNA interactions. Investigate the potential impact of chromatin modifications and local structural changes on gene expression.

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Epigenetic Changes in Cancer
Cancer Research with RNA-Seq

Studies of epigenetic alterations in cancer, such as aberrant methylation and transcription factor binding, can provide insight into important tumorigenic pathways. As altered methylation often activates or silences genes, changes in the epigenome can affect gene expression and the rate of cancer progression. Learn more about cancer epigenetics.

Methylation Analysis for Complex Disease
Microbial RNA-Seq

Genome-wide methylation profiling can help researchers understand the functional mechanisms at work in complex disease cases. Aberrant cytosine methylation can impact gene expression, and has been implicated in many disease processes, such as Alzheimer’s disease and asthma. Learn more about complex disease research.

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Epigenome Roadmap
Epigenome Roadmap

A collection of research papers that systematically characterize epigenomic landscapes in primary human tissues and cells.

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Epigenetic Contributions to Addiction
Epigenetic Contributions to Addiction

Marilee Morgan discusses the use of NGS to correlate epigenetic signatures with brain image scans of substance abusers.

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Nutrition: Matter Over Mind
Nutrition: Matter Over Mind

A review of current research into the impact of epigenetics on human health.

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Epigenetics and Obesity
Epigenetics and Obesity

Dr. Samani and team conduct an epigenetic-wide association study and uncover obesity-drive methylation signatures.

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Nature vs. Nurture
Nature vs. Nurture

An introduction to epigenetics and the role it plays in cancer, genetic disease, and development.

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Methylation Field Guide
Methylation Field Guide

A comprehensive guide on array and sequencing-based methylation methods.

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Epigenome Blueprint
Epigenome Blueprint

A consortium generating 100 reference epigenomes to understand gene activation and repression in healthy and diseased human cells.

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Learn Epigenetics
Learn Epigenetics

A SEPA-funded initiative at the Genetic Science Learning Center at the University of Utah.

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