Some diseases arise from a mutation in a single gene. Others, known as complex diseases, do not follow this single-gene inheritance pattern. Instead, they result from interactions between genes and the environment. Complex diseases include Alzheimer’s disease, asthma, Parkinson’s disease, diabetes, heart conditions, and others.
Genetic disease research requires analyzing the many factors involved in complex diseases. Next-generation sequencing (NGS) and microarrays deliver the throughput, accuracy, and versatility needed for assessing the diverse aspects of disease biology. With these technologies, you can process multiple samples quickly, establish unbiased starting points for studies, progress through research faster, and ultimately publish sooner.
An increasing amount of genetic disease research is dedicated to finding the causal variants that contribute to disease manifestation and severity. More studies are revealing associations between genetic variants and disease phenotypes. Learn more about causal variant discovery »
After a genetic variant is associated with a disease, further study can reveal its effects on protein structure, gene expression, and gene regulation. Sequencing- and array-based methods can be used to determine variant effects. Learn more about candidate variant validation »
DNA methylation has been implicated in many disease processes. Illumina offers solutions for analyzing genome-wide methylation patterns using both sequencing and arrays. Learn more about methylation profiling »
Gene expression and regulation analysis studies can reveal insights into the biological impact of genomic alterations observed in complex diseases. Learn about our sequencing solutions for gene expression profiling and regulation »
Learn how genomic technologies are introducing new avenues for understanding complex disease etiology on a molecular level.
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See how NGS offers new methods for exploring and understanding the cellular activity of disease.
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Learn why Dr. Abraham Palmer at the University of Chicago uses the HiSeq 2500 System to identify genes that influence behavior.
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