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Forensic Genomics

More conclusive results in forensic testing are now a practical reality thanks to advances in genomics. Illumina next-generation sequencing (NGS) technology and informatics deliver far more insight from forensic DNA than traditional methods, with a much higher resolution than ever before possible. You’ll find the answers you need efficiently with a greater degree of certainty, with the focused power of the MiSeq FGx Forensic Genomics System.

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MiSeq FGx Forensic Genomics System
Developmental Validation of the MiSeq FGx System Webinar

Join a live webinar event and hear from Dr. Cydne Holt, Associate Director of Forensic Genomics, about the performance of the ForenSeq DNA Signature Prep Kit and ForenSeq Universal Analysis Software as well as comparisons to orthogonal SNP and STR allele calling methods.

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The Scientist Top 10
Forensic DNA Testing for Criminal Casework

In forensic genomics laboratories worldwide, challenging DNA samples must sometimes be interrogated multiple times to attempt to extract a full set of data. If this is unsuccessful, the samples might be set aside as partial, inconclusive data.

Illumina sequencing by synthesis (SBS) technology on the MiSeq FGx Forensic Genomics System analyzes all global short tandem repeats (STRs). It also addresses nearly 200 forensically relevant single nucleotide polymorphisms (SNPs). This is all done with one simple, unified workflow, from less than 1 ng of sample.

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Forensic Profiling for DNA Databases

Illumina SBS technology remedies the problem of "limited real estate" faced by length-based genotyping via capillary electrophoresis. This is because SBS imposes no relevant limit on the number of loci that can be simultaneously analyzed. With the MiSeq FGx System, crime laboratories can simultaneously analyze every locus now in use, plus hundreds more.

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mtDNA Analysis to Identify Missing Persons

mtDNA analysis is used to extract genetic data from small forensic samples found in less than ideal condition. SBS has the potential to transform this process, with the MiSeq FGx capable of indexing 96 samples in one sequencing run. Its simple one-step workflow efficiently delivers results, which can help speed investigations.

Illumina next-generation sequencing also provides deep coverage of areas of interest. With this technology, research scientists can now analyze human samples even hundreds and thousands of years old. The information can unlock secrets about long-vanished individuals.

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Disaster Victim Identification

The goal of genetic analysis of samples from a mass fatality is to extract as much genetic information as possible from highly compromised samples. Analysts must evaluate the evidentiary material and decide which assay method to perform. Choosing one assay often precludes the ability to perform another. With Illumina NGS, these tradeoffs are eliminated.

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Validation and Casework Implementation in 2016

Expert interviews on how the MiSeq FGx System is being used in forensic DNA casework labs, and on the forefront of genetic investigative leads.

Criminal Casework
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MiSeq FGx Forensic Genomics System Webcast
MiSeq FGx Forensic Genomics System Webcast

View an exclusive demonstration and experience the simplicity of the MiSeq FGx System.

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NGS for Forensic Genomics
Overview: NGS for Forensic Genomics

View an introduction to next-generation sequencing and its applications for forensic genomics.

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mtDNA Analysis on the MiSeq
The Power of mtDNA Heteroplasmy

Hear Mitch Holland of Penn State explain how high-throughput sequencing is helping us realize the power of mtDNA heteroplasmy.

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mtDNA Poster
mtDNA Poster

Improved Human MtDNA Analysis using Next-generation Sequencing and Cloud-based Computing and Storage.

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Forensic Genomics Video Part 1
Forensic Genomics Videos Part 1 and 2

Hear from Dr. Bruce Budowle about the future of forensic genomics in this 2 Part Video Series. View Video Part 1

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Forensic Genomics Webinar
Forensic Genomics Webinar

Learn how the Illumina forensic genomics workflow can transform forensic applications.

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Future of Forensic Genomics
Future of Forensic Genomics

Researchers use NGS to obtain more information-rich data and answer more complex forensic questions.

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Recreating a Face Based on DNA
Recreating a Face Based on DNA

Researchers identify genetic variants that influence facial features to enable facial imaging from DNA.

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Harnessing NGS to Solve Crimes
Harnessing NGS to Solve Crimes

Criminalists use MiSeq FGx for high-resolution DNA profiling to build better forensic DNA databases.

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