Infinium OncoArray-500K BeadChip

This comprehensive, high-density microarray kit enables research into cancer predisposition and risk.

~2,304 samples per week

Sample throughput

Fixed markers: ~500,000 Custom marker add-on capacity: Up to 120,000 (with + kit versions)

Number of markers

See full details in the specifications table

Overview

The Infinium OncoArray-500K contains 500,000 SNPs with a genome-wide backbone of 250,000 tag SNPs. Additional SNPs include genetic variants associated with breast, colorectal, lung, ovarian, and prostate cancers plus SNPs covering ancestry, quantitative traits, pharmacogenetics, and fine-mapping of common cancer susceptibility loci. To support additional research requirements, the Infinium OncoArray-500K can be tailored to incorporate up to 120,000 custom beadtypes.*

The Infinium OncoArray-500K was developed in collaboration with leading experts from the OncoArray consortium†, and draws on many of the features of the successful Collaborative Oncological Gene-environment Study (iCOGS) array1. Designed with candidate SNPs identified by the consortium, the OncoArray provides a cost-effective means to assess candidate variants potentially associated with cancer risk.

The Infinium OncoArray-500K uses a 24-sample high-throughput screening (HTS) BeadChip to enable maximum throughput, productivity, and genotyping accuracy. Using the proven iScan System, the Infinium OncoArray-500K is designed to combine affordability with high-density content, providing insight into the relationship between gene variants and cancer predisposition in five of the most prevalent cancers.

* For additional information about custom add-on content, contact your Illumina account manager or sales specialist.

View Manifest (Array Content) Files


Specifications


Required products

Match your chosen kit size to the number of samples you run at a time. Each kit is processed as a single batch and is not designed to be divided across multiple experiments. If you are processing several low-throughput batches, order multiple small kits.

/ Results

Applications

Example workflow

2
Process and Scan
3
Analyze

Related applications and methods

Infinium OncoArray-500K BeadChip Kit (48 samples)

WG-355-1001

Each Infinium OncoArray-500K BeadChip can process twenty-four samples and analyze >500,000 loci. Each package contains 2 BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 48 DNA samples.

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Infinium OncoArray-500K BeadChip Kit (288 samples)

WG-355-1002

Each Infinium OncoArray-500K BeadChip can process twenty-four samples and analyze >500,000 loci. Each package contains 12 BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 288 DNA samples.

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Infinium OncoArray-500K v1.0 BeadChip Kit (1152 samples)

WG-355-1003

Each Infinium OncoArray-500K BeadChip can process twenty-four samples and analyze >500,000 loci. Each package contains 48 BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 1152 DNA samples.

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Infinium OncoArray-500K+ BeadChip Kit (48 samples)

WG-355-1011

Infinium OncoArray-500K+ v1.0 (48 samples)

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Infinium OncoArray-500K+ BeadChip Kit (288 samples)

WG-355-1012

Infinium OncoArray-500K+ v1.0 (288 samples)

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Infinium OncoArray-500K+ BeadChip Kit (1152 samples)

WG-355-1013

Infinium OncoArray-500K+ v1.0 (1152 samples)

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References

1. www.nature.com/icogs/primer/cogs-project-and-design-of-the-icogs-array

† The OncoArray consortium is an international collaboration of leading experts from the NCI-supported Genetic Association and Mechanisms in Oncology (GAME-ON) consortiumGenome CanadaGenome Quebec, and Cancer Research UK.

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