fC-Seal
fC-Seal
In fC-Seal, 5hmC residues in the genome are blocked with regular glucose, and 5fC residues are reduced to 5hmC by NaBH4. The newly generated 5hmC residues are then modified, enriched, and sequenced.
In fC-Seal, 5hmC residues in the genome are blocked with regular glucose, and 5fC residues are reduced to 5hmC by NaBH4. The newly generated 5hmC residues are then modified, enriched, and sequenced.