Identify DNA-protein interactions that affect gene regulation

DNA-Protein Interaction Analysis

Analysis of DNA-protein interactions provides researchers with insight into regulation events that are critical for many biological processes and disease states. This epigenetic information is complementary to DNA sequencing, genotyping, gene expression, and other forms of genomic analysis.

DNA-Protein Interaction Analysis

By combining chromatin immunoprecipitation (ChIP) and massively parallel sequencing, ChIP-Seq accurately surveys interactions between protein, DNA, and RNA, enabling the interpretation of regulation events central to many biological processes and disease states. Use ChIP-Seq to identify transcription factor binding sites, track histone modifications across the genome, and narrow in on chromatin structure and function.

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Analyzing DNA-Protein Interactions with Sequencing
Sequencing Method Explorer

Use this interactive tool to explore experimental next-generation sequencing (NGS) library preparation methods compiled from the scientific literature.

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Sequencing Method Explorer
Optimal Cluster Density Best Practices

Watch Illumina scientists discuss how over- and underclustering can affect your sequencing data. Learn about common clustering issues and ways to prevent them.

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How to Achieve Consistent Cluster Density

Cluster density has a significant impact on run performance, specifically data quality and total output. Learn how to achieve more consistent cluster densities.

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Detect DNA-Protein Interactions in Tumors
Detect DNA-Protein Interactions in Tumors

Altered transcription factor binding is a common epigenetic pattern in cancer. ChIP-Seq experiments provide researchers with a complete snapshot of DNA regions associated with a protein of interest. Learn more about cancer epigenetics.

Genome Wide Association Studies
Gene Expression in Common Disease

Understanding the genetic architecture of complex diseases relies heavily on discovery and characterization of genetic variants associated with a particular disease. Learn more about GWAS for common variant discovery associated with disease.

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Sequencing Methods Review
DNA Sequencing Methods Review

A collection of library prep and sequencing methods, including ChIP-Seq, compiled from peer-reviewed publications.

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Epigenome Roadmap
Epigenome Roadmap

A collection of research papers that systematically characterize epigenomic landscapes in primary human tissues and cells.

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Epigenome Blueprint
Epigenome Blueprint

A consortium generating 100 reference epigenomes to understand gene activation and repression in healthy and diseased human cells.

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The ENCODE Consortium built a comprehensive parts list of relevant proteins on the genome and set standards for generating and analyzing ChIP-Seq data.