Analysis of DNA-protein interactions provides researchers with insight into regulation events that are critical for many biological processes and disease states. This epigenetic information is complementary to DNA sequencing, genotyping, gene expression, and other forms of genomic analysis.
By combining chromatin immunoprecipitation (ChIP) and massively parallel sequencing, ChIP-Seq accurately surveys interactions between protein, DNA, and RNA, enabling the interpretation of regulation events central to many biological processes and disease states. Use ChIP-Seq to identify transcription factor binding sites, track histone modifications across the genome, and narrow in on chromatin structure and function.
Altered transcription factor binding is a common epigenetic pattern in cancer. ChIP-Seq experiments provide researchers with a complete snapshot of DNA regions associated with a protein of interest. Learn more about cancer epigenetics.
Gene expression and regulation analysis studies can reveal insights into the biological impact of genomic alterations observed in complex diseases. Learn more about gene expression profiling and regulation.