Genomic tools for diagnostic testing

Molecular Diagnostics

Advances in genetic analysis tools for molecular diagnostics are revolutionizing the practice of medicine, improving prenatal and reproductive care, enabling earlier disease detection, and advancing treatment of heritable disease. Novel assays based on next-generation sequencing and microarray technologies are being developed, helping us unlock the power of the genome. When laboratories begin to take advantage of these tools, we will see changes in health care in ways never before imagined, ultimately paving the way to improving human health.

NGS Resources for Pathologists

This document presents a collection of educational resources about applying NGS.

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The MiSeqDx instrument is the first FDA-regulated and CE-IVD-marked in vitro diagnostic (IVD) next-generation sequencing (NGS) system. Designed specifically for the clinical laboratory environment, the MiSeqDx instrument is a benchtop sequencer that incorporates an easy-to-follow workflow and an integrated software design to enable sample tracking, user traceability, and results interpretation.* Built on Illumina sequencing by synthesis (SBS) chemistry, the MiSeqDx instrument provides accurate, reliable screening and diagnostic testing, providing the speed and accuracy to enrich human understanding of disease, enabling earlier detection and reducing the time to diagnosis. Illumina offers a growing menu of assays and kits enabling clinical laboratories to create and deploy NGS-based molecular diagnostic tests for cystic fibrosis, colorectal cancer, and a wide range of other applications.

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Flexible Power for Molecular Diagnostics

The Extended RAS Panel is the first FDA-approved NGS test that can detect multiple RAS gene mutations for colorectal cancer in a single test. The panel assesses 12 codons in KRAS/NRAS simultaneously to determine the presence of 56 clinically relevant mutations. The test is indicated to aid in the identification of patients with colorectal cancer for treatment with Vectibix® (panitumumab) based on the absence of detected mutations. The Extended RAS Panel is intended to be used on the Illumina MiSeqDx instrument.

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Guidelines for Evaluation of Colorectal Cancer

The Extended RAS Panel meets the newly published guidelines from the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and American Society of Clinical Oncology for the evaluation of RAS mutations in colorectal cancer samples.

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Early detection and treatment for cystic fibrosis can significantly improve a patient’s quality of life. See more of the data that matters with the MiSeqDx System, the first IVD NGS platform for accurate, comprehensive cystic fibrosis testing. The system includes the MiSeqDx instrument and two assays: the Cystic Fibrosis 139-Variant Assay that detects 139 clinically relevant CFTR variants and the Cystic Fibrosis Clinical Sequencing Assay that accurately captures variants in the protein coding regions and intron/exon boundaries of CFTR.

Learn More About Cystic Fibrosis Testing

Take advantage of powerful NGS technology by building your own IVD assays with the MiSeqDx instrument and TruSeq Custom Amplicon Kit Dx. Together, the MiSeqDx instrument and TruSeq Custom Amplicon Kit Dx provide the accuracy and reliability needed to bring NGS into clinical labs. As a result, you can increase the number of molecular diagnostic applications available to your customers.

Learn More About Developing Your Own NGS IVD Assays

Reimbursement coding for clinical laboratories performing molecular diagnostic tests has changed. The Molecular Pathology (MoPath) codes, updated in 2013, reflect the purpose of the test instead of the methods used. In addition, MoPath codes specific for NGS tests have been proposed. In this section, we discuss how these changes affect reimbursement for molecular diagnostic services moving forward.

Learn More About MoPath Codes and Their Impact

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*Detailed results reports are available for the MiSeqDx Cystic Fibrosis 139-Variant Assay, the MiSeqDx Cystic Fibrosis Clinical Sequencing Assay, and the Extended RAS Panel.