Human microbiome analysis is the study of microbial communities found in and on the human body. The goal of human microbiome studies is to understand the role of microbes in health and disease.
Traditionally, studying samples from human skin, stool, or blood relied on time- and labor-intensive microbiology techniques of growing and isolating individual organisms followed by phenotypic or genotypic analysis. Microbial community profiling within a single sample was not possible with these methods.
The advent of next-generation sequencing (NGS) enabled several high-profile collaborative projects including the Human Microbiome Project and MetaHIT, which have published a wide range of data on the human microbiome using NGS as a foundational tool.
The throughput and cost savings of NGS have fueled metagenomics studies capable of surveying the genomes of entire communities, including those of unculturable organisms.
The MiSeq System is enabling the Saca la Lengua project research team to sequence thousands of samples to identify the variety of bacteria and fungi that live in the human mouth.Read Interview
Researchers at Microba are investigating the genomes of microbes to improve our understanding of human health, disease, and microbial evolution.Read Interview
Dental calculus, the hard deposit the dentist scrapes off your teeth, is the only part of your body that fossilizes during your lifetime.View Video
A comprehensive workflow for NGS-based microbiome profiling delivers enhanced insights for metagenomics studies.Read Article
Complex diseases have increased dramatically over the last few decades. Many of these are associated with abnormalities in composition of the microbiome, but the cause/effect relationship still remains to be understood. To address this important question, on September 16, 2016, the University of Nebraska announced a visionary initiative to change the way people experience food, agriculture and medicine through the new Nebraska Food for Health Center (NFHC).