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To evaluate mutations known to affect the efficacy of Vectibix* for treatment of metastatic colorectal cancer,1,2 Illumina offers the Praxis Extended RAS Panel. This Food and Drug Administration (FDA)-approved next-generation sequencing (NGS) kit assesses 12 codons in KRAS/NRAS to simultaneously determine the presence of 56 activating mutations.
The Praxis Extended RAS Panel is used to aid in the identification of patients eligible for treatment with Vectibix. The panel is intended to be used on the MiSeqDx instrument. On-instrument Local Run Manager software helps create a sequencing run, monitor run status, and analyze the sequencing data. It then delivers an easy-to-interpret report to guide therapy decisions accurately and efficiently.
*Vectibix is a registered trademark of Amgen, Inc.
The Praxis Extended RAS Panel is a qualitative in vitro diagnostic test using targeted high throughput parallel sequencing for the detection of 56 specific mutations in RAS genes [KRAS (exons 2, 3 and 4) and NRAS (exons 2, 3 and 4)] in DNA extracted from formalin-fixed, paraffin-embedded (FFPE) colorectal cancer (CRC) tissue samples. The Praxis Extended RAS Panel is indicated to aid in the identification of patients with colorectal cancer for treatment with Vectibix® (panitumumab) based on a no mutation detected test result. The test is intended to be used on the Illumina MiSeqDx instrument.
Praxis Extended RAS Panel Package Insert.
Summary of Safety and Effectiveness Data.
Vectibix full Prescribing Information, including Boxed Warnings.
For In Vitro Diagnostic Use.
Contact an Illumina representative for regional availability.
Data Sheet | PDF < 1 MB
Extended RAS Panel Support Documentation