The Infinium CytoSNP-850K v1.2 BeadChip is the first SNP-based human microarray to leverage the latest input from the international community for cytogenomics studies. The gene list was defined based on content from the International Collaboration for Clinical Genomics (ICCG)1 and the Cancer Genomics Consortium (CGC)2, providing a comprehensive view of cytogenomic activity.* This enhanced SNP coverage enables copy number calls as small as 10 kb in regions associated with genetic disease.
Thorough Coverage for Constitutional and Cancer Applications
The Infinium CytoSNP-850K v1.2 BeadChip provides comprehensive coverage of cytogenetically relevant genes on a proven platform, helping researchers find valuable information that may be missed by other technologies. It contains approximately 850,000 empirically selected single nucleotide polymorphisms (SNPs) spanning the entire genome with enriched coverage for 3,262 genes of known cytogenetics relevance in both constitutional and cancer applications.
High Detection Sensitivity for Low-level Mosaics
A unique attribute of the Infinium array technology is the use of long 50-mer probes that have high specificity to the SNP target. This increases sensitivity for low-level mosaics3 and offers high resolution for copy-neutral loss of heterozygosity (LOH). In addition, each SNP is represented in at least 15x redundancy to increase the signal-to-noise ratio for making accurate copy number variation (CNV) and absence of heterozygosity (AOH) calls across the genome. As few as 10 consecutive probes are necessary to make accurate CNV calls, demonstrating the high performance level of the Infinium assay.
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