The Infinium CytoSNP-850K v1.3 BeadChip is the first SNP-based human microarray to leverage the latest input from the international community for cytogenomics studies. The gene list was defined based on content from the International Collaboration for Clinical Genomics (ICCG)1 and the Cancer Genomics Consortium (CGC)2, providing a comprehensive view of cytogenomic activity.* This enhanced SNP coverage enables copy number calls as small as 10 kb in regions associated with genetic disease.
The Infinium CytoSNP-850K v1.3 BeadChip provides comprehensive coverage of cytogenetically relevant genes on a proven platform, helping researchers find valuable information that may be missed by other technologies. It contains approximately 850,000 empirically selected single nucleotide polymorphisms (SNPs) spanning the entire genome with enriched coverage for 3,262 genes of known cytogenetics relevance in both constitutional and cancer applications.
A unique attribute of the Infinium array technology is the use of long 50-mer probes that have high specificity to the SNP target. This increases sensitivity for low-level mosaics3 and offers high resolution for copy-neutral loss of heterozygosity (LOH). In addition, each SNP is represented in at least 15x redundancy to increase the signal-to-noise ratio for making accurate copy number variation (CNV) and absence of heterozygosity (AOH) calls across the genome. As few as 10 consecutive probes are necessary to make accurate CNV calls, demonstrating the high performance level of the Infinium assay.
Researchers from the MGZ Medical Genetic Center are using the Infinium CytoSNP-850K BeadChip and the TruSight Cancer Panel to analyze chromosomal abnormalities.Read More
The Infinium CytoSNP-850K BeadChip enables cytogenetics researchers to scan the entire genome for common and rare genomic alterations.Read More
Cytogenetics to Cytogenomics: An Introduction to Genomic Technologies
White Paper | PDF 2 MB
Analyzing FFPE Tissue Samples with the Infinium CytoSNP-850K v1.1 BeadChip
Application Note | PDF < 1 MB
Cytogenetic Analysis by High-Resolution SNP Array
Application Note | PDF 2 MB
Custom Cluster File Creation for Improved Copy Number Analysis
Technical Note | PDF < 1 MB
Data Sheet | PDF | 5 versions
CytoSNP-850K BeadChip Support Documentation
Infinium LiHa and Infinium RoMa Operating Manual Documentation
Infinium CytoSNP-850K BeadChip Checklist Documentation
Infinium CytoSNP-850K BeadChip Assay Reference Guide Documentation
Infinium Assay Lab Setup and Best Practices Documentation
Infinium Assay Consumables and Equipment List Documentation
*ICCG and CGC were previously the International Standard of Cytogenomics Array (ISCA) and the Cancer Cytogenetics Microarray Consortium (CCMC), respectively.