TruSeq Methyl Capture EPIC Library Prep Kit

This kit combines next-generation sequencing with epigenetic insights to accelerate biomarker discovery and understand methylation’s role in gene regulation.Read More...
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TruSeq-Methyl Capture EPIC Library Prep Kit (12 samples, 4 indexes)



TruSeq-Methyl Capture EPIC Library Prep Kit (48 samples, 12 indexes)



Product Highlights

Targeted Methyl-Seq offers a balanced, cost-effective choice between whole-genome bisulfite sequencing and methylation arrays that can support both screening and biomarker discovery study objectives.1 TruSeq Methyl Capture EPIC Library Prep supports researchers seeking a deeper understanding of the role of methylation in gene regulation:

Comprehensive methylation-site content: Offers significantly higher coverage of emerging epigenetic regions of interest compared to other Methyl-Seq kits currently on the market (See Supporting Data section, Epigenetic Regions Covered).

Maximize discovery power, minimize cost: Efficiently query differentially methylated bases to conserve research dollars.

Convenient kit configuration: Includes bisulfite conversion, library prep, target enrichment, and purification reagents in a single kit for hassle-free ordering.

User-friendly data analysis: Analyze sequence data in the BaseSpace Sequence Hub with methylation apps designed for biologists.


Method-Specific Workflow Example


Supporting Data and Figures


This kit requires a PCR enzyme kit such as the Kapa Hifi Uracil+ (Cat No. KK2801), available separately.

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Infinium MethylationEPIC Kit

Robust methylation profiling microarray with extensive coverage of CpG islands, genes, and enhancers. Use for epigenome-wide association studies.

TruSeq DNA Methylation Kit

Converts bisulfite-treated, single-stranded DNA into an Illumina sequencing library. Enables comprehensive whole-genome DNA methylation analysis.

TruSeq ChIP Library Preparation Kit

Simple, cost-effective chromatin immunoprecipitation sequencing (ChIP-Seq) DNA library preparation, with master mixes and robust multiplex capabilities.

  1. Masser DR, Stanford DR, and Freeman WM. Targeted DNA methylation analysis by next-generation sequencing. J Vis Exp. 2015; (96).
  2. Agilent SureSelect MethylSeq target regions. Accessed 14 June 2016.
  3. Roche Nimblegen CpGiant target regions. Accessed 14 June 2016.