The Infinium Global Screening Array-24 BeadChip combines multi-ethnic genome-wide content, curated clinical research variants, and quality control (QC) markers for precision medicine research.
The genome-wide content was selected for high imputation accuracy at minor allele frequencies of >1% across all 26 1000 Genomes Project populations. The clinical research content includes variants with established disease associations, relevant pharmacogenomics markers, and curated exonic content based on ClinVar, NHGRI, PharmGKB, and ExAC databases. QC content enables sample identification and tracking for large-scale genomics and screening applications.
Predesigned booster content is available as an add-on to the array.
With over 15 million samples worth of BeadChips sold, the Global Screening Array's global adoption provides a network of human disease researchers, healthcare networks, consumer genomics companies, and genomic service providers to help power discovery.
The array supports genotyping and CNV calling for sample types including saliva, blood, and buccal swabs. The format allows processing of hundreds to thousands of samples per week with a 3-day workflow for population-scale studies.
The array provides a genomic tool for clinical research applications including disease risk profiling studies, pharmacogenomics research, wellness characterization, and complex disease discovery.
Version 3 of the Global Screening Array leverages the most up to date and relevant clinical research screening markers derived from ClinVar, CPIC, and PharmGKB.
As leading databases such as ClinVar continue to rapidly add new variants, Illumina is dedicated to ensuring the variants interrogated on the GSA remain updated and relevant. The launch of the Infinium GSA-24 v3.0 BeadChip includes an update of key variants found in ACMG 59 genes. A growing number of precision medicine research initiatives around the world are leveraging these variants to screen populations for the following applications:
|Infinium Global Screening Array-24 Kit||Infinium Global Diversity Array-8 Kit||Infinium Omni2.5-8 Kit|
|Description||An economical next-generation genotyping array that enables population-scale genetics, translational research, variant screening studies, and precision medicine research by combining highly optimized multiethnic genome-wide content, curated clinical research variants, and QC markers.||The 8-sample Infinium Diversity Array provides targeted coverage of more than 4800 key genes across the genome. Approximately 1.8M markers are included on the BeadChip for high exonic coverage in regions of disease relevance, providing highly accurate copy number variation calls, and an average resolution of 1.5Mb.||8-sample arrays with high throughput and optimized tag SNP content, including full support of copy number variation applications, designed to be highly customizable and maximally informative for studying diverse world populations.|
|Nucleic Acid Type||DNA||DNA||DNA|
|Number of Markers||Fixed markers: ~ 654,027
Custom marker add-on capacity: Up to 100,000
|Fixed markers: ~2,381,000, Custom marker add-on capacity: None|
|Number of Samples||24 samples per array||8 samples per array|
|Sample Throughput||~5760 samples/week max per iScan (throughput and scan times may vary based on laboratory and system configurations.)||~1728 samples/week per iScan (max throughput and scan time may vary based on lab and system configurations)|
Fast Infinium array analysis and broad genome coverage support personal genetic testing services and database development.Read Interivew
MyDNA recently began partnering with Illumina customers using the Global Screening Array and Asian Screening Array in their genetic test offerings.Read Interview
Researchers perform large GWAS studies with the Global Screening Array to identify disease-associated DNA risk loci and develop PRSs for clinical validation.Read Interview
Explore pharmacogenomics (PGx) research technologies and understand how variations in the human genome affect our response to medications. Insights from these studies can ultimately help maximize the benefits of treatment plans while reducing health care costs.Learn More About PGx Research
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