The newest addition to the
Molecular testing in lung cancer has been at the forefront of precision oncology. The use of targeted therapies is associated with improved outcomes in some patients, and currently requires testing multiple biomarkers, such as EGFR mutations, ALK fusions, and ROS fusions, among others. Recently, TMB gained prominence as a biomarker that demonstrates better response and survival from immune checkpoint inhibitors in patients exhibiting high TMB, necessitating the need for comprehensive sequencing. Reliable measurement of TMB in a tumor-only workflow requires sequencing of approximately 1Mb or greater, specific and sensitive variant calling, as well as bioinformatic methods to flag and remove germline variants. Given the increasing number of biomarkers required to fully understand the optimal therapeutic course, assays like TruSight Oncology 500—one of the largest and most comprehensive panels to-date—encompasses all of these biomarkers, making it an ideal choice for cancer researchers today.
“The importance of tumor mutational burden as a biomarker to predict immune checkpoint inhibition response continues to grow in non-small cell lung cancer,” said
“While many methods are arising that measure TMB, these methods may differ in their variant calling performance and their gene content, affecting measurement,” said Dr. Carina Heydt, a molecular biologist at the
Pharmaceutical partners and payers are shifting toward deeper, broader sequencing to help predict which patients may benefit from new treatments including immunotherapies, targeted therapies and the many potential combinations. Recently,
“By focusing on our most differentiated oncology products, we can meet the needs of our customers and provide a comprehensive NGS panel that includes all of the known and anticipated biomarkers associated with targeted and immune-based therapies,” said
TruSight Oncology 500 offers deep, adaptable, and accessible sequencing power:
- Goes beyond current cancer guidelines and clinical trials – The deep investigational power of TSO 500 covers a large number of genes – alterations that are being used to identify patients for clinical trials – while covering 1.94Mb of the genome to measure TMB.
- Unlocks immunotherapy research – Rigorously developed and accurate TMB and MSI algorithms, with a dedicated tumor-only workflow, while also offering the flexibility to detect a vast majority of known genetic variants, whether it be small variants, gene amplifications, de novo fusions, or splice variants.
- Integrated tumor-only, RNA+DNA workflow: The ability to run RNA and DNA biomarkers into one workflow enables a lab to evaluate all relevant biomarkers at the same time. In addition, being able to run tumor-only workflow enables cost savings for a lab since there is no need to run a normal sample each time.
For additional product and availability information, please visit: www.illumina.com/TruSightOncology500
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