Reaching a better understanding of tumor immunogenicity and immunotherapy

Supporting a personalized medicine approach with NGS technologies

Cancer Immunotherapy Research

Immuno-oncology is an emerging field that has taken great strides in the fight against cancer, bolstered by a refined understanding of how tumors evade the natural immune response. Leading immuno-oncology researchers are leveraging next-generation sequencing to discover biomarkers and apply genomics to personalized immunotherapy.

Research into the mechanisms tumors use to evade the immune response have led to promising therapeutic targets. These therapies boost the ability of the immune system to target cancer, or limit the tumor’s ability to evade the natural immune response.

Advancing Cancer Immunotherapy Research

Immunotherapy research is growing as scientists identify biomarkers to potentially associate with favorable therepeutic responses. See how the throughput capability of NGS could help advance this research.

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Immuno-oncology Battle Lines: Equipping the Body to Fight Cancer From Within

Since the late 1800s, the field of immuno-oncology has been exploring the immune system and the development, progression, and treatment of cancer. With over a century's worth of discoveries as the guide, the past decade has seen an explosion in the translation of this research into new treatment modalities, often with unprecedented success.

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Immuno-Oncology Battle Lines Video

Studies have shown that response to certain therapies depends on numerous factors. NGS can be used in several ways to monitor these dynamic interactions, in real-time and with high analytical sensitivity.

Tumor Microenvironment and Immune Composition

Various factors in the microenvironment can influence the ability of the immune system to expand and infiltrate tumors.

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Tumor Mutational Load and Antigen Detection

Efficient assessment of mutations and understanding their correlation to immune response may help to develop new therapeutic methods.

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Cancer Microbiome Research

An emerging body of evidence indicates that microbes in the gut can influence the ability of the immune system to fight cancer.

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Immunotherapy Research Publications

Illumina technology has facilitated discovery in the immuno-oncology field through various genomic applications. Read published research findings.

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Featured Publications: Cancer Immunotherapy Research

High-throughput sequencing has shown remarkable utility in cancer and immunology research, as well as in the development of individualized immunotherapy.

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Illumina offers several library preparation and sequencing options with access to data analysis options for Immuno-Oncology Research. Streamlined workflows and flexible kit configurations accommodate multiple study designs.

Approximately 90% of the world’s sequencing data are generated using Illumina sequencing by synthesis (SBS) chemistry.*

Click on the below to view products for each workflow step.

RNA Access

The TruSeq RNA Access library prep kit provides a low-cost solution for analyzing human RNA isolated from limited or low-quality samples, including FFPE.

TruSeq Exome

TruSeq Exome Library Prep Kit is a cost-effective library preparation and exome enrichment solution.

TruSight Tumor 170

TruSight Tumor 170 assesses both DNA and RNA for 170 genes associated with common solid tumors and Tumor Mutational Burden (TMB).

TruSeq Stranded Total RNA Library Prep Kit

A robust, highly scalable whole-transcriptome analysis solution for a variety of species and sample types.

NovaSeq Series

Flexibility and unprecedented throughput for virtually any genome, sequencing method, and scale of project.

HiSeq 3000/HiSeq 4000 Systems

Patterned flow cell technology results in high throughput, low price per sample, and enhanced speed and performance.

HiSeq 2500 System

High throughput on a scalable platform for sequencing dozens to hundreds of cancer exomes per run.

NextSeq Series

Flexible configurations that support up to 12 exomes per run.

BaseSpace RNA-Seq Apps

Immuno-Oncology filter for RNA sequencing analysis.

Isaac Enrichment App

Uses the Isaac Genome Alignment Software and the Isaac Variant Caller for exome data analysis.

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Keeping Pace with Immuno-oncology
Identifying Biomarkers of Resistance

Eliezer Van Allen, MD highlights how NGS can help identify biomarkers of response and resistance to cancer immunotherapy.

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Participant Stratification in Immuno-Oncology
Participant Stratification in Immunotherapy Research

Genomics scientists discuss how advances in immuno-oncology research resulting from NGS help better stratify subjects for clinical trials.

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Keeping Pace with Immuno-oncology
Keeping Pace with Immuno-oncology Research

NGS technology can accelerate biomarker identification and bring down costs for research subject screening and safety monitoring.

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Genomic Technologies for Cancer Research
Genomic Technologies for Cancer Research

Learn the numerous ways that genomic technologies can be applied to tumor biology.

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Unmasking the Viral Etiology of Cancer and Immune Disease
Unmasking the Viral Etiology of Cancer and Immune Disease

Dr. Emilie Hultin and her team at the Karolinska Institute use Illumina sequencers to identify novel HPV types correlated with non-melanoma.

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Using NGS to Aid the Immune System in Targeting Cancers
Using NGS to Aid the Immune System in Targeting Cancers

An overview of exciting new fields of immunotherapy research, and how NGS helps to move them forward.

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Immuno-oncology Informatics Applications Using NGS
Immuno-oncology Research Informatics Applications Using NGS

Improved informatics tools enable neoantigen discovery and tumor microenvironment analysis

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*Data calculations on file. Illumina, Inc., 2015