Cellular research of complex diseases

Array and NGS methods enable global genetic analyses of cellular function in the etiology of complex diseases

Functional Cellular Research

Traditionally, cell biology research seeks to understand the contribution/function of a single gene, gene family, or signaling pathway to a complex disease. Researchers use signal-based methods such as microscopy, flow cytometry, protein blotting, and others. Given the multifactorial nature of complex diseases, this approach can be time-consuming and does not always result in conclusive findings.

Array and next-generation sequencing (NGS) technologies from Illumina can broaden cellular research beyond the conventional methods of protein interactions and single-gene functional studies. Illumina technology enables analysis across the genome, transcriptome, and epigenome. NGS results can inform experimental design and subsequent studies, saving time and allowing researchers to publish sooner.

See how NGS offers new methods for exploring and understanding the cellular activity of disease.

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Genetic Studies of Memory

Dr. Matt Huentelman uses single-cell RNA sequencing to study the genetic and neurological variables affecting learning and memory.

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SureCell Whole Transcriptome Analysis 3' Library Prep Kit: This kit supports transcriptome profiling of hundreds to tens of thousands of single cells in a given experiment.

NextSeq 550 System: This system combines sequencing and array scanning on a single platform.

BaseSpace Sequence Hub Single-Cell RNA-Seq App: Designed for use with the SureCell WTA 3' Library Prep Kit, this app performs cell and gene counting, filtering, and reporting.

From Genotype to Phenotype

Dr. Lachlan Jolly discusses insights into gene function in cell models of brain development.

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Single-Cell RNA Sequencing
Single-Cell RNA Sequencing

Providing a high-resolution view of cell-to-cell variation.

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Cellular Research Review
Cellular Research Review

This review highlights recent publications that used Illumina technology for single-cell sequencing.

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Understanding Stem Cell Development
Understanding Stem Cell Development

Single-cell RNA sequencing is helping scientists characterize the processes that guide early cellular development.

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Mapping Neural Diversity with Single-Cell RNA-Seq
Mapping Neural Diversity with Single-Cell RNA-Seq

The ability to analyze gene expression signatures from individual cells is transforming the way neurons are classified.

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