Sequencing the HLA region can provide critical insight into immune disorders. Achieving high-resolution human leukocyte antigen (HLA) typing results with conventional methods requires multiple assays, systems, and analysis programs. HLA typing by next-generation sequencing (NGS) generates unambiguous, phase-resolved HLA typing results using a single assay, system, and analysis program.
Sequencing HLA genes has been notoriously difficult due to high levels of sequence homology, dense variability, and poor characterization of the thousands of HLA alleles in the population. Highly accurate and robust Illumina sequencing by synthesis (SBS) chemistry is the most successful and widely adopted NGS technology worldwide.* Find out why this technology is becoming the platform of choice for HLA sequencing.
RNA-Seq and HLA typing are increasing the power and efficiency of a target discovery platform.Read More
Researchers query the genome with NGS and perform HLA genotyping to identify novel risk loci for immune-mediated disease.Read More
Drawing upon the genetic diversity of Brazilians, researchers develop an HLA variation database.Read More
The TruSight HLA Sequencing Panel v2 produces high-resolution typing of 11 HLA loci. This comprehensive sample-to-report solution for HLA typing includes reagents and software optimized for HLA analysis. A simplified workflow enables turnaround time of less than 48 hours and increased efficiency with less than 4.5 hours of hands-on time.