Next-generation Sequencing-based Solution Provides Accurate, Fast and Scalable End-to-end Genome-wide Noninvasive Prenatal Testing
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VeriSeq NIPT Solution v2 (Photo: Business Wire)
VeriSeq NIPT Solution v2 provides accurate information about fetal chromosomal status as early as 10 weeks of gestation using a single maternal blood draw. This noninvasive test provides an option to screen for aneuploidy in all autosomes, chromosomes X & Y, and partial deletions and duplications greater than 7 Mb across the genome. Due to its high-sensitivity and high-specificity (low false-positive and false-negative rates), NGS-based NIPT minimizes the need for invasive testing procedures. The automated, reliable solution provides reagents, instruments, installation and training, and offers unprecedented turnaround times; laboratories can process up to 96 samples in approximately one day.
“Genome‐wide cell-free DNA screening allows not only for the detection of common chromosomal aneuploidies, but also enables the identification of rare autosomal aneuploidies (RAAs), as well as partial deletions and duplications that are ≥7 Mb in size. Most RAAs are non-viable and result in a miscarriage. However, in the mosaic state they may persist and result in congenital malformations, intellectual disabilities, growth restriction, unfavorable pregnancy outcome, as well as fetal uniparental disomy,” said Professor
The clinical accuracy of VeriSeq NIPT Solution v2, with respect to outcomes determined by a clinical reference standard assessment, was demonstrated by evaluating more than 2,300 plasma samples from pregnant women with singleton and twin pregnancies undergoing prenatal screening for fetal chromosome aneuploidies and partial deletions and duplications of 7 Mb or greater. The study determined that VeriSeq NIPT Solution v2 provided highly sensitive and specific results – 98.8 percent passed assay quality control on the first pass.
Click here for more information on VeriSeq NIPT Solution v2.
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