Illumina DRAGEN Bio-IT Platform

The Illumina DRAGEN (Dynamic Read Analysis for GENomics) Bio-IT Platform provides ultra-rapid secondary analysis of next-generation sequencing (NGS) data.Read More...
The Illumina DRAGEN Bio-IT Platform offers
  • Robust speed1,2: Processes an entire human genome at 30× coverage in about 25 minutes
  • Accurate data: Detects small variants with high analytical sensitivity and specificity3
  • Flexible solutions: Enables data analysis onsite or in the cloud
  • Various applications: Analyzes sequencing data from whole-genome, whole exome, and targeted panels
Ultra-Rapid Analysis

The DRAGEN Platform can process NGS data for an entire human genome at 30× coverage in about 25 minutes on premise vs. > 15 hours with a traditional CPU-based system. It set two world speed records for genomic data analysis.1,2

Cost-Efficient Solution

The DRAGEN Platform can reduce on-premise investments in server clusters and utilization of cloud computing resources.

Highly Accurate Results

In the 2018 PrecisionFDA Hidden Treasures – Warm Up Challenge, The DRAGEN Platform received the highest score in five out of six accuracy measures for whole-genome variant calling among platforms that recognized all 50 variants.3

Diverse Applications

The DRAGEN Platform analyzes sequencing data from whole genomes, whole exomes, targeted panels, germline and somatic datasets, and RNA sequencing experiments.

The DRAGEN Platform enables labs of all sizes and disciplines to do more with their genomic data. The DRAGEN Platform uses highly reconfigurable field-programmable gate array technology (FPGA) to provide hardware-accelerated implementations of genome analysis algorithms, such as BCL conversion, mapping, alignment, sorting, duplicate marking, and haplotype variant calling. Fundamental features of the DRAGEN Platform address common challenges in genomic analysis, such as lengthy compute times and massive volumes of data.

Without compromising accuracy, the DRAGEN Platform delivers quickness, flexibility, and cost efficiency. The reprogrammable nature of the DRAGEN Platform enables Illumina to develop custom algorithms and allows for improvements to accommodate future applications.

DRAGEN On-Premise and in the Cloud Solutions

DRAGEN Platform on-premise and in the cloud offerings enable you to select the DRAGEN Platform that best meets your needs.
DRAGEN pipelines can be used on-premise, or cloud-based options are available at BaseSpace Sequence Hub.

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DRAGEN On-Premise

The on-premise DRAGEN Platform allows customers to analyze and store their data locally.

DRAGEN Platform on-premise can replace up to 40 traditional compute instances, reducing hardware and maintenance costs. Using proprietary technology, the DRAGEN Platform conducts secondary analysis in a fraction of the time while still maintaining high accuracy.

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DRAGEN in the Cloud

For customers desiring to share data with collaborators, the DRAGEN Platform is available in the cloud via BaseSpace Sequence Hub. DRAGEN in the cloud provides the same accuracy and cost savings as on-premise, coupled with the flexibility and scalability of the Amazon Web Services (AWS) cloud. The DRAGEN Platform in the cloud is enabled by Amazon FPGA instances (EC2 F1) and leverages the storage features of Amazon S3 for secure storage of large amounts of data.

Illumina DRAGEN Germline Pipeline The DRAGEN Germline Pipeline provides end-to-end (BCL ➝ VCF) NGS analysis, including advanced error model calibration for increased accuracy, and repeat expansion detection and genotyping through Illumina Expansion Hunter.
Illumina DRAGEN Somatic Pipeline The DRAGEN Somatic Pipeline includes tumor-only and tumor–normal modes, designed for detecting somatic variants in tumor samples
Illumina DRAGEN RNA Gene Fusion Detection Pipeline The DRAGEN RNA Gene Fusion Detection Pipeline performs transcriptome analysis starting with splice junction discovery and alignment, followed by gene fusion detection.
Illumina DRAGEN Joint Genotyping/Population Pipeline The DRAGEN Joint Genotyping/Population Pipeline calls variants jointly across multiple genomes and scales to thousands of samples at expedited speeds with uncompromising accuracy.
Illumina DRAGEN CNV Pipeline The DRAGEN CNV Pipeline performs copy number variant (CNV) analysis for germline and somatic exomes and genomes. Various levels of filtering can be applied to mitigate false positives before emitting the final calls.
Illumina DRAGEN Methylation Pipeline The DRAGEN Methylation Pipeline offers multiple operating modes, including reference-only alignment and annotation-assisted.
Illumina DRAGEN Map + Align Pipeline The DRAGEN Map + Align pipeline is capable of ultra-rapid mapping and aligning DNA and RNA for both exomes and genomes.
DRAGEN Reference Builder This app accepts FASTA files, and builds the proprietary reference used by the DRAGEN apps.
View Video
The Broad Institute

Collaborators Anthony Philippakis from The Broad Institute, and Susan Tousi of Illumina, discuss how integration of GATK with Illumina sequencers and implementation of the DRAGEN Platform may facilitate hardware acceleration and standardization of data analysis.

View Video

Children’s Hospital of Philadelphia

The DRAGEN pipeline processed 1,000 whole pediatric genomes in two hours and twenty-five minutes. The feat set the set the Guinness World Records title for Fastest time to analyze 1,000 human genomes1.

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Rady Children’s Hospital

A Guinness world record was set for Fastest Genetic Diagnosis in 19.5 hours. The DRAGEN Platform was used to significantly increase the speed of mapping and aligning genomic data once sequenced.2

Read Article            

In the 2018 PrecisionFDA Hidden Treasures – Warm Up Challenge, The DRAGEN Platform received the highest score in five out of six accuracy measures for whole-genome variant calling among platforms that recognized all 50 variants.3

Read Article            
Population Sequencing

Rapidly analyze the sequenced genomes; accelerate reanalysis as computational tools improve over time.

NICU and Genetic Disease

Reduce time required for genomic analysis, when fast results can be a critical factor.

Sequencing Centers

Stay ahead of the continuing analysis demand with hardware-accelerated algorithms.


Analyze animals and plants of varying genomic complexities, using a provided reference.

Clinical and Translational Research

Analyze targeted exome data with rapid turnaround and high accuracy to ensure reproducibility and high-quality results.

  1. Bio IT World. Children’s Hospital Of Philadelphia, Edico Set World Record For Secondary Analysis Speed. October 23, 2017. Accessed September 19, 2018.
  2. The San Diego Union Tribune. Rady Children's Institute sets Guinness world record. February 12, 2018. Accessed September 19, 2018.
  3. Precision FDA Hidden Treasures Warm Up. Accessed September 14, 2018.

Frequently Purchased Together

Product Literature

BaseSpace Apps Quick Guide

Product Information Sheet | PDF< 1 MB

BaseSpace Sequence Hub Data Sheet

Data Sheet | PDF3 MB

DRAGEN Overview Data Sheet

Data Sheet | HTML

Manuals and Support Information

All DRAGEN Bio-IT Platform Support 

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