The epigenome comprises the chemical modifications that shape the physical structure of the genome. It regulates gene expression, enabling select genes to be active at different times during the cell life cycle. Epigenetics play a significant role in growth, development, and disease progression. The epigenome changes in response to diet, stress, and other environmental factors.
Illumina offers a broad portfolio of sequencing- and array-based epigenetic analysis tools that provide robust, simple-to-use, and cost-efficient solutions for studying epigenetic modifications and their impact on gene regulation. By working with leading epigenomics experts, Illumina ensures its solutions meet the field's rapidly evolving needs.
Investigate methylation patterns quantitatively across the genome using sequencing- and array-based techniques.Learn More
Gain insight into protein and DNA interactions. Investigate the potential impact of chromatin modifications and local structural changes on gene expression.Learn More
The number of published studies using multiple genomic methods has dramatically increased in recent years.* Visit our content hub to find resources about how you can complement your current approach with another method to help enable breakthroughs from variant identification to validation.Learn More
Studies of epigenetic alterations in cancer, such as aberrant methylation and transcription factor binding, can provide insight into important tumorigenic pathways. As altered methylation often activates or silences genes, changes in the epigenome can affect gene expression and the rate of cancer progression. Learn more about cancer epigenetics.
Genome-wide methylation profiling can help researchers understand the functional mechanisms at work in complex disease cases. Aberrant cytosine methylation can impact gene expression, and has been implicated in many disease processes, such as Alzheimer’s disease and asthma. Learn more about complex disease research.
*Data calculations on file. Illumina, Inc., 2017.