Epigenetics is the study of heritable changes in gene activity caused by mechanisms other than DNA sequence changes. Epigenetic analysis research can involve studying alterations in DNA methylation, DNA-protein interactions, chromatin accessibility, histone modifications, and more.
Illumina offers a broad portfolio of next-generation sequencing (NGS)- and array-based epigenetic analysis tools that provide robust, simple-to-use, and cost-efficient solutions for studying these epigenetic modifications and their impact on gene regulation. By working with leading epigenomics experts, Illumina ensures its solutions meet the field's rapidly evolving needs.
Investigate methylation patterns quantitatively across the genome using sequencing- and array-based techniques.Learn More
Gain insight into protein–DNA interactions. Investigate the potential impact of chromatin modifications and local structural changes on gene expression.Learn More
Use ATAC-Seq to evaluate regions of open chromatin across the genome. ATAC-Seq can be performed on bulk cell populations or single cells at high resolution.Learn More
Researchers use methylation arrays and NGS to investigate the epigenetics behind cancer metastasis.Read Article
Researchers use NGS to study DNA-protein interactions, analyze gene expression, and assess coding exons.Read Article
Epigenome-wide association studies identify cell signaling disruption that potentially contributes to the negative downstream effects of a high body mass index.Read Article
In plants, chromatin accessibility – the primary mark of regulatory DNA – is relatively static across tissues and conditions. This scarcity of accessible sites that are dynamic or tissue-specific may be due in part to tissue heterogeneity in previous bulk studies.
Join us for this webinar on single-cell ATAC-Seq of Arabidopsis thaliana. The speakers discuss an analytical framework to infer the regulatory networks that govern plant development.View Webinar
Studies of epigenetic alterations in cancer, such as aberrant methylation and transcription factor binding, can provide insight into important tumorigenic pathways. Learn more about epigenetic changes in cancer.
Genome-wide methylation profiling can help researchers understand the mechanisms behind complex diseases. Aberrant methylation has been implicated in complex disorders such as Alzheimer’s disease and asthma. Learn more about complex disease research.
*Data calculations on file. Illumina, Inc., 2017.