Immune-Related Genetic Variation
Illumina technology can advance immunology research by helping elucidate immune cell function and signaling. The causes of complex autoimmune diseases (such as lupus, rheumatoid arthritis, and multiple sclerosis) and other immunological disorders are still poorly understood.
Array and next-generation sequencing (NGS) solutions from Illumina can help immunology researchers gain insight into potential autoimmune disease mechanisms, the immune repertoire, and the functional consequences of immune-related genetic variation. Illumina NGS provides the quality, throughput, and read lengths required by the research community to map the immune response at high resolution.
Immunology Research Review
View summaries of peer-reviewed publications showing the diverse ways in which immunologists use NGS.
Read ReviewNGS in Immune Repertoire Analysis
NGS is proving to be a powerful tool to map the vast repertoire of immune cells that are capable of recognizing a seemingly boundless array of targets.1 Repertoire sequencing has enabled researchers to identify unique receptor variants found in individuals with susceptibility to autoimmune disorders, hematological malignancies, and other diseases.2
T Cell Receptor Repertoire Analysis
Researchers unravel disease mechanisms by sequencing the T cell receptor (TCR) repertoire as well as mitochondrial DNA and piwi-interacting RNA..
Featured Immunology Research Articles
Precision Immunotherapies Using Tumor-Specific HLA Ligands
RNA-Seq and human leukocyte antigen (HLA) typing are increasing the power and efficiency of a target discovery platform.
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HLA Genetics & Autoimmune Disease
Researchers query the genome with NGS and perform high-throughput genotyping to identify novel risk loci for immune-mediated disease.
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NGS Proves Invaluable for Biomarker Discovery
Researchers use NGS for cancer gene expression analysis, immunology research, and immunotherapy biomarker studies.
Read ArticleImmunology Research Products
AmpliSeq for Illumina Immune Repertoire Plus, TCR beta Panel: Investigate T cell diversity and clonal expansion by sequencing T cell receptor (TCR) beta chain rearrangements.
AmpliSeq for Illumina TCR beta-SR (Short Read) Panel: FFPE-compatible panel for measuring T cell diversity and clonal expansion in tumor samples by sequencing TCR beta chain rearrangements.
AmpliSeq for Illumina Immune Response Panel: Targeted RNA expression panel investigating 395 genes involved in tumor-immune system interactions.
Infinium Immunoarray: Evaluate autoimmune disorder and immune function–associated genetic variants on a single microarray.
Single Cell Omics and Cellular Immunology Research
In episode 45 of the Illumina Genomics Podcast, Dr. Shalin Naik discusses the use of single cell genomics to understand the immune system.
Understanding Tumor Immunogenicity
NGS can help researchers identify mutations that enable tumors to evade the immune response, as well as neoantigens that can boost T cell-mediated immunity.
Learn More About Immuno-Oncology Research
Additional Resources
Driving IBD Discovery with Integrative Genomics
Dr Carl Anderson discusses integrated genomic research approaches in inflammatory bowel disease (IBD) research.
Unravelling the Mystery of Autoimmunity
In Illumina Genomics Podcast episode 46, Dr. Carola Vinuesa discusses how NGS can unravel the complex interaction of cells and molecules that regulate autoimmunity.
Cancer and Immunology Research Review
Read publication reviews showing the utility of NGS for immunology-related cancer research.