Gain insights into immunological diseases

Immunology Research

Illumina technology can advance immunology research by helping elucidate immune cell function and signaling. The causes of complex autoimmune diseases (such as lupus, rheumatoid arthritis, and multiple sclerosis) and other immunological disorders are still poorly understood.

Array and next-generation sequencing (NGS) solutions from Illumina can help immunology researchers gain insight into potential autoimmune disease mechanisms, the immune repertoire, and the functional consequences of immune-related genetic variation. Illumina NGS provides the quality, throughput, and read lengths required by the research community to map the immune response at high resolution.

Immunology Research Publication Review
Immunology Research Review

View summaries of peer-reviewed publications showing the diverse ways in which immunologists use NGS.

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NGS is proving to be a powerful tool to map the vast repertoire of immune cells that are capable of recognizing a seemingly boundless array of targets.1 Repertoire sequencing has enabled researchers to identify unique receptor variants found in individuals with susceptibility to autoimmune disorders, hematological malignancies, and other diseases.2  

T Cell Receptor Repertoire Analysis

Researchers unravel disease mechanisms by sequencing the T cell receptor (TCR) repertoire as well as mitochondrial DNA and piwi-interacting RNA..

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Featured Immunology Research Articles

 
Tumor-Specific HLA Ligands
Precision Immunotherapies Using Tumor-Specific HLA Ligands

RNA-Seq and human leukocyte antigen (HLA) typing are increasing the power and efficiency of a target discovery platform.

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Targeted DNA Analysis
HLA Genetics & Autoimmune Disease

Researchers query the genome with NGS and perform high-throughput genotyping to identify novel risk loci for immune-mediated disease.

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Breast Cancer
NGS Proves Invaluable for Biomarker Discovery

Researchers use NGS for cancer gene expression analysis, immunology research, and immunotherapy biomarker studies.

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AmpliSeq for Illumina Immune Repertoire Plus, TCR beta Panel: Investigate T cell diversity and clonal expansion by sequencing T cell receptor (TCR) beta chain rearrangements.

AmpliSeq for Illumina TCR beta-SR (Short Read) Panel: FFPE-compatible panel for measuring T cell diversity and clonal expansion in tumor samples by sequencing TCR beta chain rearrangements.

AmpliSeq for Illumina Immune Response Panel: Targeted RNA expression panel investigating 395 genes involved in tumor-immune system interactions.

Infinium Immunoarray: Evaluate autoimmune disorder and immune function–associated genetic variants on a single microarray.

Single Cell Omics and Cellular Immunology Research

In episode 45 of the Illumina Genomics Podcast, Dr. Shalin Naik discusses the use of single cell genomics to understand the immune system.

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Understanding Tumor Immunogenicity

NGS can help researchers identify mutations that enable tumors to evade the immune response, as well as neoantigens that can boost T cell-mediated immunity.

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T Cell-Mediated Immunity
Driving IBD Discovery with Integrative Genomics
Driving IBD Discovery with Integrative Genomics

Dr Carl Anderson discusses integrated genomic research approaches in inflammatory bowel disease (IBD) research.

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NGS to Survey Chromatin Landscape
Unravelling the Mystery of Autoimmunity

In Illumina Genomics Podcast episode 46, Dr. Carola Vinuesa discusses how NGS can unravel the complex interaction of cells and molecules that regulate autoimmunity.

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Cancer and Immune System Research Review
Cancer and Immunology Research Review

Read publication reviews showing the utility of NGS for immunology-related cancer research.

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References
  1. Woodsworth D.J., Castellarin M., and Holt R.A. Sequence analysis of T-cell repertoires in health and disease. Genome Med. 2013; 5:98.
  2. Robins H. Immunosequencing: applications of immune repertoire deep sequencing. Curr Opin Immunol. 2013; 25: 646-652.