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Illumina microarray

Infinium Global Clinical Research Array-24 v1.0 Kit

The Global Clinical Research Array offers exceptional coverage of key genome-wide clinical content with a highly scalable workflow.

5760

Sample throughput

24 samples per array

Number of samples

1,157,992

Number of markers

See full details in the specifications table

Overview

This BeadChip offers excellent genome-wide variation analysis for population genetics and precision medicine research. It is designed for studying diverse populations, including underrepresented ethnic groups. It features:

  • Approximatley 1.2M markers that span the human genome
  • Ethnically diverse backbone
  • Coverage of genes necessary for molecular blood typing, clinical research, and population studies
  • Enhanced flexibility with capacity for up to 50K custom markers
  • Automated, scalable workflow provides a 2-2.5-day turnaround time
  • Formamide-free reagents support environmentally friendly protocol
  • Infinium EX format compatible with powerful Infinium liquid handling instruments with advanced software

Specifications

Assay type Infinium EX
Automation capability Liquid handling robots, Automated array loader
Hands-on time 2 – 2.5 day
Input quantity 100 ng
Instruments iScan System
Nucleic acid type DNA
Number of markers Fixed markers: 1,157,992, Custom marker add-on capacity: Up to 50,000
Number of samples 24 samples per array
Sample throughput ~5760 samples per week
Specialized sample types Blood
Species category Human
Technology Microarray

Required Products

20051293 Infinium Automated Pipetting System with ILASS

20031992 Infinium EX/XT Starter Kit 220V OR the 20031915 Infinium EX/XT Starter Kit 110V

11291093 iScan System

/ Results

FAQ

You will need the following products:

  • iScan System
  • Infinium EX array kit, such as the Global Screening Array-48 v4.0 kit
  • Infinium Automated Pipetting System with ILASS, to be used for post-amplification steps
  • Infinium Amplification System (Optional), to be used to automate pre-PCR steps (WGA)
  • Infinium EX/XT starter kit

Throughput:

  • The ability to run 48 samples per BeadChip on GSA v4 and scale up to 11,520 samples per week
  • iScan System with Infinium liquid handler instruments can scale up to hundreds of thousands of samples per year 

Automation:
Illumina Lab Automation Software Solution (ILASS) guides the user through the steps of the workflow via an intuitive user interface and provides on-deck validation, meaning the consumables loaded on the liquid handling robots are verified prior to use regardless of whether the customer is using LIMS. Real-time integration with cloud-based Clarity LIMS supports compliance with eSignature capability, audit trails, reagent and lot tracking, preset protocols, and privacy and security controls, which is critical for high-throughput customers.

  • Whole-genome amplification step is 3 hr for Infinium EX compared with 24 hr for legacy Infinium workflows, reducing total workflow time by 20%
  • Input DNA required for Infinium EX genotyping workflow is 100 ng compared with 200 ng for legacy workflows
  • Reagents are EH&S-friendly and formamide free
  • ILASS provides an improved UI and support experience
  • Updated automation and software allow integration with cloud-based analysis

Both arrays feature a multiethnic genome-wide backbone with content for population studies, variant screening, and precision medicine research. In addition to this, Infinium Global Clinical Research Array-24 v1.0 covers additional clinical research markers from ACMG 73 and gnomAD exome to increase coverage of underrepresented populations.

/ Results

Applications

Example workflow

1
Select content

Infinium Global Clinical Research Array-24

2
Process and scan
3
Track, analyze and report

Related applications and methods

Pharmacogenomics (PGx)

Pharmacogenomics, the study of how variations in the human genome affect our response to medications, may help reduce adverse drug reactions and medical costs.

Population genomics

Population genomics programs integrate large-scale genomic and clinical data into a learning health system, driving health care innovation.

Genomics in drug discovery and development

Explore innovative genomic analysis solutions designed to inform drug discovery efforts and support development of targeted therapeutics.

Documentation

Product literature

Literature is not currently available for this product.

Support documentation

A dedicated support section is not currently available for this product

Compare

Infinium Global Clinical Research Array-24 v1.0 Kit Infinium Global Diversity Array-8 Kit Infinium Global Screening Array-24 Kit
Assay type Infinium EX Infinium LCG Infinium HTS
Automation capability Liquid handling robots, Automated array loader Liquid handling robots, Automated array loader Liquid handling robots, Automated array loader
Hands-on time 2 – 2.5 day
Input quantity 100 ng 200 ng DNA 100 ng
Instruments iScan System iScan System iScan System
Nucleic acid type DNA DNA DNA
Number of markers Fixed markers: 1,157,992, Custom marker add-on capacity: Up to 50,000 1,825,277 fixed markers. Custom marker add-on capacity: Up to 175K. 654,027 fixed markers. Custom marker add-on capacity: Up to 100K. 
Number of samples 24 samples per array 8 samples per array 24 samples per array
Sample throughput ~5760 samples per week ~1728 samples per week ~5760 samples per week
Specialized sample types Blood Blood, FFPE tissue, Buccal swabs, Saliva Blood, FFPE tissue, Buccal swabs, Saliva
Species category Human Human Human
Technology Microarray Microarray Microarray

Selection tools:

Figures

Clinical research content on the Global Screening Array

Content was expertly selected from scientifically recognized databases to create a highly informative array for clinical research applications. Variant counts may be subject to change.

Infinium Global Clinical Research Array-24 v1.0 Kit (24 samples)

20065215

Includes one, 24-sample BeadChip and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 24 DNA samples. Requires 100 ng DNA for input. Each kit is processed as a single batch.

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Infinium Global Clinical Research Array-24 v1.0 Kit (96 samples)

20068337

Includes four, 24-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 96 DNA samples. Requires 100 ng DNA for input. Each kit is processed as a single batch.

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Infinium Global Clinical Research Array-24 v1.0 Kit (1152 samples)

20068338

Includes 48, 24-sample BeadChips and reagents for amplifying, fragmenting, hybridizing, labeling, and detecting 1152 DNA samples. Requires 100 ng DNA for input. Each kit is processed as a single batch.

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Infinium Global Clinical Research Array-24+ v1.0 Kit (24 spl)

20068351

Infinium Global Clinical Research Array-24+ v1.0 Kit (24 spl)

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Infinium Global Clinical Research Array-24+ v1.0 Kit (96 spl)

20068352

Infinium Global Clinical Research Array-24+ v1.0 Kit (96 spl)

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Infinium Global Clinical Research Array-24+ v1.0 Kit (1152 spl)

20068353

Infinium Global Clinical Research Array-24+ v1.0 Kit (1152 spl)

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Illumina Hybridization Oven (110V)

SE-901-1001

Includes a rotating hybridization wheel with variable rotation speed of 5–60 rpm and a temperature range from 0°C to 100°C. Holds up to 24 BeadChips at one time. (110 V)

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Illumina Hybridization Oven (220V)

SE-901-1002

Includes a rotating hybridization wheel with variable rotation speed of 5–60 rpm and a temperature range from 0°C to 100°C. Holds up to 24 BeadChips at one time. (220 V)

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Infinium XT Hybridization Chamber (1)

20011755

Infinium XT Hybridization Chamber supporting the hybridization of DNA samples to BeadChips.

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Hybridization Oven

High-capacity, temperature-controlled hybridization (hyb) oven customized for Illumina microarray assays.

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