The HiSeq X Ten System is the world’s first to break the $1000 genome barrier for human whole-genome sequencing (WGS). The system consists of a set of 10 HiSeq X ultra-high-throughput instruments that deliver over 18,000 human genomes per year. Each HiSeq X System can sequence a human genome at 30x coverage or greater for significantly less than $1000 in consumables.*
*When used at scale, the HiSeq X Ten delivers a $1000 genome, inclusive of instrument depreciation, DNA extraction, library preparation, and estimated labor for a typical high-throughput genomics laboratory. Calculated in 2014.
The HiSeq X Ten System was purpose-built for population-scale WGS. The 10 instruments of a HiSeq X Ten System generate a staggering level of throughput for processing tens of thousands of samples. The HiSeq X Ten empowers scientists, institutions, and nations to create a comprehensive catalog of human and species variation, forge population-based references, drive far-reaching discoveries, and advance the study of cancer and complex diseases at a record pace.
HiSeq X Sequencing System also enables cost-effective WGS for non-human species with unrivaled throughput. The HiSeq X System delivers high coverage in a variety of areas, including agriculture and model organism research in the pharmaceutical industry. By providing ultra-high throughput and a low price point per genome, the HiSeq X System provides customers with an opportunity to reshape the economics and scale of WGS beyond the human species.
The technological advancements provided by the HiSeq X Series change the economics of variant detection, driving price parity between whole-exome and whole-genome sequencing for variant detection in exonic regions. WGS also provides greater coverage uniformity and higher sensitivity at lower depths of coverage compared to exome sequencing.1
Opening an unconstrained view of the entire genome, not just the 2% represented by the exome, lets researchers discover and identify important disease variants both inside and outside coding regions, and detect structural variants and genomic rearrangements.
The HiSeq X Five System enables ultra-high-throughput WGS at a cost and scale appropriate for large genome centers, and offers a scalable path to $1000 human genome capacity. With a lower initial capital investment, the HiSeq X Five System consists of 5 individual HiSeq X instruments, which together can sequence over 9000 genomes per year.
The Illumina HiSeq X instrument will be on display as an example of how sequencing technology is playing a crucial part in helping amass the data in the 100,000 Genomes Project that will allow scientists to do pioneering research.View Video
Led by Carola Vinuesa, MD, PhD, researchers at Australian National University are performing human whole-genome sequencing and whole-exome sequencing on HiSeq X Ten and HiSeq 2500 Systems to identify variants associated with lupus and other autoimmune disease.Read Article
Drs. Carlos Bustamante, Stephen Kingsmore, and John Mattick provide their perspective on the impact of high-throughput and population sequencing in clinical research and the role they'll play in the future of medicine.Read Article
The cBot 2 System streamlines the sequencing workflow by automating cluster generation. It is a required accessory instrument for HiSeq sequencers.
Kits include SBS reagents, clustering reagents, and patterned flow cells for increased cluster density and simplified image analysis, compared to non-patterned flow cells.
Simple, all-inclusive whole-genome sequencing (WGS) library preparation that provides accurate and comprehensive coverage of complex genomes.