NovaSeq 6000Dx Applications & Methods
NovaSeq 6000Dx Instrument Applications
Dual modes of operation enable both IVD testing and clinical research, opening new possibilities across a range of sample types, sequencing methods, and applications.
Key Diagnostic Application: Target Enrichment
Illumina DNA Prep with Enrichment Dx is a fast, integrated workflow for a wide range of applications. It supports a broad DNA input range and multiple sample types including blood, genomic DNA, and formalin-fixed, paraffin-embedded (FFPE) tissue.
Application note
Target Enrichment on the NovaSeq 6000Dx Instrument
Prep
Illumina DNA Prep with Enrichment Dx
This IVD-compliant solution enables clinical laboratories to add targeted enrichment panels to their menu of diagnostic applications.
Sequence
NovaSeq 6000Dx Reagent Kits
Reagents for the NovaSeq 6000Dx provide IVD-compliant, ready-to-use cartridge-based reagents for cluster generation and SBS.
Analyze
DRAGEN for Illumina DNA Prep with Enrichment Dx for NovaSeq 6000Dx
The DRAGEN server features an integrated FPGA chip for accurate, ultrarapid NGS secondary data analysis with DRAGEN for NovaSeq 6000Dx and a dedicated analysis module for Illumina DNA Prep with Enrichment Dx.
Key Clinical Research Applications (in Research Mode)
Prep
Illumina DNA PCR-Free Prep
A high-performing, fast, and integrated workflow for sensitive applications such as human whole-genome sequencing.
DNA Prep
A fast, integrated workflow for a wide range of applications, from human whole-genome sequencing to amplicons, plasmids, and microbial species.
TruSeq DNA Nano
Generate whole-genome sequencing libraries and efficiently interrogate samples with limited available DNA.
TruSeq DNA PCR-Free
Simple, all-inclusive whole-genome sequencing (WGS) library preparation that provides accurate and comprehensive coverage of complex genomes.
Sequence
NovaSeq 6000 Reagent Kits
Reagent kits for the NovaSeq 6000 provide ready-to-use cartridge-based reagents for cluster generation and SBS. NovaSeq 6000Dx is compatible with RUO reagent kits.
Analyze
DRAGEN Server Germline
The DRAGEN Germline with features integrated FPGA chip for accurate ultra rapid NGS secondary analysis with DRAGEN for NovaSeq 6000Dx in Research Mode.
BaseSpace Sequence Hub
Leverage DRAGEN Germline or DRAGEN Somatic on Illumina BaseSpace Sequence Hub, or stand-alone DRAGEN server (purchased separately) for accurate, comprehensive, and efficient secondary analysis.
BCL Convert
Utilize the NovaSeq 6000Dx DRAGEN server in RUO mode to convert BCL files to FASTQ.
Use converted FASTQ files as the input to any custom secondary analysis. Less user touchpoints and improved workflow efficiency.
Reduce storage and operational cost by up to 5x with lossless FASTQ ORA compression.
Prep
Illumina DNA Prep with Enrichment
A fast, integrated workflow for a wide range of applications providing targeted resequencing for custom panels, fixed panels, and whole-exome enrichment.
Illumina DNA Prep with Exome 2.0 Plus Enrichment
A high-performance, fast, and complete whole-exome sequencing kit.
Sequence
NovaSeq 6000 Reagent Kits
Reagent kits for the NovaSeq 6000 provide ready-to-use cartridge-based reagents for cluster generation and SBS. NovaSeq 6000Dx is compatible with RUO reagent kits.
Analyze
Paired DRAGEN server for NovaSeq 6000Dx
Leverage the Illumina DRAGEN for Illumina DNA Prep with Enrichment (IDPE) App in RUO mode for accurate and efficient secondary analysis.
BCL Convert
Utilize the NovaSeq 6000Dx DRAGEN server in RUO mode to convert BCL files to FASTQ.
Use converted FASTQ files as the input to any custom secondary analysis. Less user touchpoints and improved workflow efficiency.
Reduce storage and operational cost by up to 5x with lossless FASTQ ORA compression.
Prep
TruSight Oncology 500 High-Throughput (HT)
TruSight Oncology 500 HT enables in-house comprehensive genomic profiling of tumor samples with flexibility for higher sample throughput and batching options. DNA & RNA content targets 523 genes for assessment of all DNA and RNA variant types, plus TMB and MSI. Automation kits and methods are available for reduced hands-on time and scalability.
Sequence
NovaSeq 6000 Reagent Kits
Flexible sample batching allows for 16-192 samples per sequencing flow cell on the NovaSeq 6000Dx system, in RUO manual mode. Reagent kits for the NovaSeq 6000 provide ready-to-use cartridge-based reagents for cluster generation and SBS. NovaSeq 6000Dx is compatible with RUO reagent kits.
Analyze
Stand-alone DRAGEN server or Illumina Connected Analytics (ICA)
Rapid variant calling algorithm powered by DRAGEN pipelines, available locally with separate, stand-alone DRAGEN server. Secure, scalable, cloud-based variant calling is also available with DRAGEN pipelines on Illumina Connected Analytics (ICA), featuring auto-launch capability.