Microbial Genomics

Tuberculosis surveillance

Integrative NGS-based solutions for tuberculosis detection, characterization, and analysis

Tuberculosis surveillance for a world health crisis

Tuberculosis (TB) surveillance is a vital step toward eradicating a disease that is the second leading infectious disease killer worldwide, behind COVID-19.1 Caused by bacteria in the Mycobacterium tuberculosis complex (MTBC), which includes Mycobacterium tuberculosis (Mtb), TB is a treatable disease but drug-resistant TB (DR-TB) remains a public health crisis and a health security threat.1 Genomic-based TB surveillance can support public health officials in:

  • Detecting Mtb and non-TB species
  • Characterizing TB drug resistance
  • Tracking the path of transmission
  • Monitoring the evolution of mycobacterium through the emergence of novel mutations that are resistant to existing and new forms of treatment

The power of next-generation sequencing (NGS) enables outbreaks to be addressed with greater speed and confidence.

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eBook cover

NGS: An innovative approach for detecting, characterizing, and eradicating tuberculosis

NGS is fueling the future of drug-resistant TB research. This informative eBook outlines the global implications of DR-TB, details how NGS is being used to advance the World Health Organization (WHO) goal of ending TB, and overviews Illumina targeted and whole-genome sequencing workflows that can be applied to TB genomic investigations and research.​

Tuberculosis surveillance webinars: Advancing drug‑resistant TB detection with targeted NGS

Gain practical, evidence‑based insights from global experts and national TB programs implementing targeted next‑generation sequencing (tNGS) in these webinars.

Featured product

Illumina and Genoscreen Deeplex Myc-TB Combo Kit

Illumina and Genoscreen Deeplex Myc-TB Combo Kit

This kit is a tNGS panel that identifies MTBC strains and mycobacterial species while providing a solution for genotyping and predicting drug resistance mutations for MTBC strains. This is a comprehensive, culture-free solution for characterizing TB drug resistance with fast results in less than 48 hours.

View product

Featured NGS workflows

1
Prepare library
Illumina and Genoscreen Deeplex Myc-TB Combo Kit
2
Sequence
iSeq 100
MiniSeq
MiSeq
NextSeq 550
NextSeq 1000/2000
3
Analyze data
Deeplex Web App
1
Prepare library
Illumina DNA Prep
2
Sequence
iSeq 100
MiniSeq
MiSeq
NextSeq 550
NextSeq 1000/2000
3
Analyze data
SPAdes Genome Assembler on BaseSpace Sequencing Hub

Fighting drug-resistant TB with NGS

In this video, learn how NGS is transforming the fight against DR-TB by providing faster and more comprehensive detection using tNGS and WGS to help end the TB epidemic.

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Tuberculosis in the news

From TB patient to advocate

Read the story about a former TB patient and how he turned his efforts to help others beat the second-leading infectious disease killer worldwide.

Additional resources

Direct bacterial colony sequencing

Eliminate the need for separate DNA isolation and high-accuracy quantitation steps with the streamlined, cost-effective Flex Direct Colony Method.

ECCMID 2023 video of Swapna Uplekar​

In this talk, Dr Swapna Uplekar, Senior Scientific Officer at FIND, Switzerland, shows how to enable targeted NGS for detection and diagnosis of drug-resistant tuberculosis.

WHO recommends targeted NGS for DR-TB

Read the guideline from the WHO on how to get get rapid, comprehensive DR-TB insights using Deeplex‑MycTB, a test that identifies species, genotypes, and resistance to key drugs in under 48 hours.

How tNGS enables rapid TB detection

See how next‑generation sequencing cuts TB drug‑resistance detection to under 48 hours, transforming accuracy, speed, and surveillance in one streamlined workflow in this infographic.

Speak to a specialist

Interested in learning more about TB surveillance products?

References