Informative markers and flexible content on proven array platforms

Microarray Service Technology

Illumina FastTrack Services uses Infinium whole-genome genotyping and methylation arrays as well as custom iSelect arrays. It is equipped with the proven HiScan and iScan systems to help researchers unravel the complex genetic architecture behind diseases. Additionally, in-house software SNP selection and analysis tools (e.g. Assay Design Tool, GenomeStudio) optimize data precision and research scalability. Customers benefit by receiving high-quality data from proven technologies best tailored to the needs of their research.

The following table outlines Illumina FastTrack Services proven success with each technological platform.

Key Highlights of Past Performance Processed Samples Sample Success Rate (from blood extracted DNA) Average Call Rate
Infinium Services Projects 394,387 98% 99.6%
Methylation Service Projects 3,600 95% 99.5%
FastTrack Microarray Service Technology

Providing industry best data quality and content flexibility for genotyping, the Infinium genotyping assay drives the targeted consortia microarrays, cytogenetic microarrays and our iSelect custom microarrays. The Omni family offers an expanding selection of flexible arrays featuring only the most informative common and progressively rare variants for genome-wide analysis. Powerful markers selected from the International HapMap and 1000 Genomes Projects are offered and built with input from thought leaders in the human genetics research community, to ensure these markers will effectively advance your studies.

Increasing the flexibility of the platform, the Omni family of microarrays can be enhanced with hundreds of thousands of markers of custom content considered as semi-custom microarrays. Additionally, researchers can design their own microarray from the bottom-up, using 3,000 to 700,000 custom variants with the iSelect microarray platform. Both platforms offer a range of sample configurations per array to maximize high-throughput power while minimizing the cost-per-sample.

Using the Infinium genotyping technology, Illumina offers focused content for non-human organisms, including both animal and plant species. Through the agriculture consortia, a broad-range of agrigenomic applications can be designed to advance research, screening methods and deployment of these applications in the field. Illumina’s genotyping platforms enable a simple, flexible, and fast workflow that is fully automated and traceable through the FastTrack Services lab information management system (LIMS). This comprehensive offering is ideal for bio-repositories (biobanks).

Illumina FastTrack Services has been highly successful in reliably producing high quality Infinium genotyping data as depicted in this table.

Learn more about the Infinium Assay

Infinium Service Projects Average
Sample Success Rate 98%
Locus Success Rate >99% on standard products
Call Rate 99.6%
Reproducibility 99.99%
Heritability (Trios) 99.98%

Illumina’s Infinium Methylation assay provides quantitative methylation measurements at the single CpG site level, offering the highest resolution for understanding epigenetic changes. The HumanMethylation450 BeadChip offers a unique combination of comprehensive, expert-selected coverage, including 99% of RefSeq genes, 96% of CpG islands, and other content categories selected by methylation experts, making it ideal for epigenome-wide association studies (EWAS). Learn more about array-based methylation analysis.

Large-Scale Methylation Studies

Learn more about the HumanMethylation450 BeadChip - the ideal solution for large-scale methylation studies.

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The Infinium Technology

Watch the Infinium Arrays animation.

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The Infinium Technology

GenomeStudio software consists of several assay-specific modules, integrated into a single platform which provided a set of graphical and data visualization features to display results generated by different platforms. GenomeStudio modules cover the spectrum of Illumina array based applications including genotyping, methylation and immunoprotein assay analysis.

More specifically, the GenomeStudio uses data generated using Infinium assays and performs primary analysis such as raw data normalization, clustering, and genotype calling. Genotyping results are exported for use in third-party downstream analysis software. The Methylation module identifies methylation signatures across the entire genome and analyzes differences between experimental groups. It provides a wide range of graphics and visualization tools. Learn more about GenomeStudio and Download Software.

FastTrack Services deploys the HiScan and iScan systems to image all microarray service offerings. They are cutting-edge array scanners that support rapid, sensitive, and accurate imaging of Illumina BeadChips for industry-leading genetic analysis results. Both systems support Illumina's broad portfolio of innovative genetic analysis assays for genotyping, CNV analysis, DNA methylation, and gene expression profiling. Additionally, these systems are fully integrated with Illumina LIMs to maintain sample traceability.

iScan System
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For more literature on our genotyping products:

Genotyping Literature & Resources

Find out more about our custom microarray options.

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