The GDA is the commercial version of the microarray chosen by the All of Us Research Program. This program will engage one million or more volunteers living in the U.S. to contribute their health data over many years to improve health outcomes, fuel the development of new treatments for disease, and catalyze a new era of evidence-based and more precise preventive care and medical treatment. Moreover, one of the program's core values guiding development and implementation is for participants to reflect the rich diversity of the U.S. The GDA was built to meet these needs by combining highly optimized multi-ethnic, genome-wide content with curated clinical research variants.
The GDA provides the most cost-effective variant coverage within the Illumina human array portfolio. This 8-sample BeadChip features exceptional, up-to-date coverage of clinical research variants associated with disease and pharmacogenetics. The GDA is built on a high-density single nucleotide polymorphism (SNP) global backbone optimized for cross-population imputation coverage of the genome. The GDA enables polygenic risk score development and characterization of genetic architecture in diverse populations.
Predesigned booster content is available as an add-on to the array.
The GDA contains a robust genome-wide scaffold designed to tag both common and low frequency variants in global populations. This scaffold was designed through collaborations with the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) and Population Architecture using Genomics and Epidemiology (PAGE). The GDA includes content not found in 1K Genomes Project, with more than 1000 whole-genome sequences of African ancestry and populations throughout the Americas, including the US, Caribbean, and Latin and South America.
The GDA uses the 8-sample Infinium LCG format which enables laboratories to scale efficiently as needed. For flexible throughput processing, the Infinium LCG assay provides the capability to run up to 1728 samples per week using a single iScan System. The Infinium LCG assay provides a rapid, three-day workflow that allows users to gather and report data quickly.
Infinium LCG Assay Reference Guide Documentation
Global Diversity Array with Polygenic Risk Score Software Documentation
Custom Protocol Selector
Generates customized, end-to-end instructions