Pan-cancer research with molecular profiling

Molecular analysis across cancer types to understand tumor classification and potential targeted therapies

Pan-Cancer Analysis

Although all cancers are molecularly distinct, many share common driver mutations.1 Pan-cancer analysis involves assessing frequently mutated genes and other genomic abnormalities common to many different cancers, regardless of tumor origin. Using next-generation sequencing (NGS), pan-tumor projects such as The Cancer Genome Atlas2 have made significant contributions to our understanding of DNA and RNA variants across many cancer types.

Pan-cancer profiling with NGS panels enables researchers to comprehensively analyze a defined set of gene variants and aberrations associated with many common cancers, including both solid tumors and hematologic malignancies.

Molecular Analysis Across Cancer Types

Targeted sequencing offers a simple, cost-effective approach for pan-cancer profiling studies. Expert-defined pan-cancer panels eliminate the need to isolate gene targets of NGS separately, and multiplexing enables many samples to be run at the same time regardless of tumor type. Multiplexing enables pan-cancer RNA studies to be run in parallel with DNA studies for a comprehensive tumor profile.

NGS-based pan-cancer analysis follows simple workflows that can be easily scaled to large numbers of samples. Pan-cancer analysis allows the inclusion of markers from various cancer types in a single assay, positively impacting workflows and turnaround times.

Featured Pan-Cancer Articles

Pediatric Leukemia
A New View of Cancer Pathways in Pediatric Leukemia

Researchers use a targeted RNA sequencing pan-cancer panel to understand the role of fusion genes in pediatric leukemia.

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Brain Tumor Research
NGS Panels Demonstrate Value in Brain Tumor Studies

Researchers describe studies to identify diffuse glioma genetic markers, and discuss the benefits of a pan-cancer panel.

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Genomic markers create actionable insights
The Complex World of Pan-Cancer Markers

Learn about promising pan-cancer biomarkers and efforts to recharacterize cancers as mutation-based rather than organ-based.

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Our comprehensive portfolio of NGS-based pan-cancer panels and library preparation kits enables cancer researchers to run DNA and RNA assays simultaneously for a broad view of tumor mechanisms.

Illumina sequencers deliver industry-leading accuracy, generating ~90% of the world’s sequencing data.* Efficient reporting capabilities enable researchers to annotate, classify, and communicate significant findings in a standard format that facilitates data analyses and trending.

Click on the below to view products for each workflow step.

TruSight Oncology UMI Reagents

The TruSight Oncology UMI Reagents and UMI Error Correction App reduce error rates in samples to ≤0.007%, enabling the detection of low frequency variants.

TruSight RNA Pan-Cancer

Research panel targeting 1385 oncology genes for gene expression, variant and fusion detection in all RNA sample types including FFPE.

AmpliSeq for Illumina Cancer HotSpot Panel v2

Targeted research panel investigating hotspot regions of 50 genes with known associations to cancer.

TruSight Oncology 500

Comprehensive coverage of pan-cancer content, aligned with key guidelines spanning 523 cancer-relevant genes. Also assesses tumor mutational burden and microsatellite instability.

TruSight RNA Fusion

A gene fusion detection panel targeting fusion associated genes in many cancer types with the ability to detect known and novel fusion gene partners.

MiniSeq System

Simplest and most affordable solution for low-throughput targeted sequencing for pan-cancer profiling.

MiSeq System

Desktop sequencer featuring a simple NGS workflow, integrated data analysis software, and unmatched accuracy.

MiSeqDx Instrument

FDA-cleared in vitro diagnostic NGS system that also operates in research mode to generate accurate, reliable data.

NextSeq 550 System

Flexible desktop sequencers that support multiple applications, from targeted profiling to whole-genome sequencing.

BaseSpace Sequence Hub

The Illumina genomics computing environment for NGS data analysis and management.

MiSeq Reporter

Easy-to-use software for analysis and variant calling on the MiSeq System.

BaseSpace Variant Interpreter

A powerful analysis and reporting tool that provides biological insight into genomic variant data.

Local Run Manager

Easy-to-use software for automated on-instrument data analysis.

Illumina DRAGEN Bio-IT Platform

Provides accurate, ultra-rapid secondary analysis of sequencing data, including somatic datasets.

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Targeted Sequencing for Hematologic Disorder Research

Dr. Torsten Haferlach, Head of Munich Leukemia Laboratory, discusses molecular assessments of hematologic disorders.

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Nature Journal Focus: Pan-Cancer Analysis

This initiative examines similarities between genomic alterations across cancer types profiled by The Cancer Genome Atlas consortium.

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How NGS is Changing Clinical Cancer Research

Dr. Andrew Fellowes from Peter MacCallum Cancer Centre discusses how his team uses Illumina technology.

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Capturing Variant Data from the Blood

Deep analysis of exosomal DNA found in the blood of pancreatic cancer subjects offers insight into the potential of liquid biopsies.

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References
  1. Ciriello G, Miller ML, Aksoy BA, Senbabaoglu Y, Schultz N, Sander C. Emerging landscape of oncogenic signatures across human cancers. Nat Genet. 2013;45:1127-1133.
  2. Nature TCGA | TCGA Pan-Cancer Analysis (www.nature.com/tcga)

* Data calculations on file. Illumina, Inc. 2015.