Although all cancers are molecularly distinct, many share common driver mutations.1 Pan-cancer analysis involves assessing frequently mutated genes and other genomic abnormalities common to many different cancers, regardless of tumor origin. Using next-generation sequencing (NGS), pan-tumor projects such as The Cancer Genome Atlas2 have made significant contributions to our understanding of DNA and RNA variants across many cancer types.
Targeted sequencing offers a simple, cost-effective approach for pan-cancer profiling studies. Expert-defined pan-cancer panels eliminate the need to isolate gene targets of NGS separately, and multiplexing enables many samples to be run at the same time regardless of tumor type. Multiplexing enables pan-cancer RNA studies to be run in parallel with DNA studies for a comprehensive tumor profile.
NGS-based pan-cancer analysis follows simple workflows that can be easily scaled to large numbers of samples. Pan-cancer analysis allows the inclusion of markers from various cancer types in a single assay, positively impacting workflows and turnaround times.
Researchers use a targeted RNA sequencing pan-cancer panel to understand the role of fusion genes in pediatric leukemia.Read Interview
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Our comprehensive portfolio of NGS-based pan-cancer panels and library preparation kits enables cancer researchers to run DNA and RNA assays simultaneously for a broad view of tumor mechanisms.
Illumina sequencers deliver industry-leading accuracy, generating ~90% of the world’s sequencing data.* Efficient reporting capabilities enable researchers to annotate, classify, and communicate significant findings in a standard format that facilitates data analyses and trending.
Click on the below to view products for each workflow step.
The TruSight Oncology UMI Reagents and UMI Error Correction App reduce error rates in samples to ≤0.007%, enabling the detection of low frequency variants.TruSight RNA Pan-Cancer
Research panel targeting 1385 oncology genes for gene expression, variant and fusion detection in all RNA sample types including FFPE.AmpliSeq for Illumina Cancer HotSpot Panel v2
Targeted research panel investigating hotspot regions of 50 genes with known associations to cancer.
Comprehensive coverage of pan-cancer content, aligned with key guidelines spanning 523 cancer-relevant genes. Also assesses tumor mutational burden and microsatellite instability.TruSight RNA Fusion
A gene fusion detection panel targeting fusion associated genes in many cancer types with the ability to detect known and novel fusion gene partners.
Simplest and most affordable solution for low-throughput targeted sequencing for pan-cancer profiling.MiSeq System
Desktop sequencer featuring a simple NGS workflow, integrated data analysis software, and unmatched accuracy.
The Illumina genomics computing environment for NGS data analysis and management.MiSeq Reporter
Easy-to-use software for analysis and variant calling on the MiSeq System.BaseSpace Variant Interpreter
A powerful analysis and reporting tool that provides biological insight into genomic variant data.
* Data calculations on file. Illumina, Inc. 2015.