TruSight Oncology 500

Assay targeting multiple variant types, including tumor mutational burden (TMB) and microsatellite instability (MSI), even from low-quality samples. Read More...
Select Product(s)

TruSight Oncology 500 DNA Kit (48 samples)

20028213

Price
 
 

TruSight Oncology 500 DNA Kit, For Use with NextSeq (48 samples)

20028214

Price
 
 

TruSight Oncology 500 DNA/RNA Bundle, (16 indexes, 24 samples)

20028215

Price
 
 

TruSight Oncology 500 DNA/RNA Bundle, for use with NextSeq (16 indexes, 24 samples)

20028216

Price
 
 

TruSight Oncology 500 DNA Kit plus PierianDx interpretation report (16 indexes, 48 Samples)

20032624

Price
 
 

TruSight Oncology 500 DNA Kit for Use with NextSeq plus PierianDx interpretation report (16 indexes, 48 Samples)

20032625

Price
 
 

TruSight Oncology 500 DNA/RNA Bundle plus PierianDx interpretation report (16 indexes, 24 Samples)

20032626

Price
 
 

TruSight Oncology 500 DNA/RNA Kit for Use with NextSeq plus PierianDx interpretation report (16 indexes, 24 Samples)

20032627

Price
 
 

Product Highlights

TruSight Oncology 500 is a next-generation sequencing (NGS) assay that enables Comprehensive Genomic Profiling of tumor samples. It supports identification of all relevant DNA and RNA* variants implicated in various tumor types.

In addition, it accurately measures the key immunotherapy biomarkers: tumor mutation burden (TMB) and microsatellite instability (MSI).

Save Time, Money, and Samples through assay Consolidation

  • Pan-cancer content aligned with key guidelines and clinical trials
  • DNA + RNA* assay targeting 523 genes for assessment of small variants, TMB, MSI, splice variants, and fusions
  • Identify relevant alterations while achieving highly accurate results

Achieve Highly Confident Results

  • Software filters artifacts for accurate variant calling
  • Enrichment chemistry inclusive of unique molecular indexes (UMIs) for high sensitivity in variant detection
  • Based on proven Illumina platform

Unlock Immuno-Oncology

  • Panel contains immuno-oncology biomarkers TMB and MSI
  • Tumor-only workflow for simplicity and efficiency
  • TMB calling performance similar to whole-exome sequencing (WES) panels
  • Large 1.94 Mb panel and sophisticated algorithm for accurate TMB score

* The product to evaluate DNA & RNA variants is the TSO500 DNA/RNA bundle.

Frequently Purchased Together

Specifications

Method-Specific Workflow Example

 

Supporting Data and Figures

 
Detection of currently relevant DNA & RNA* variants for multiple types of cancer. Some key biomarkers included:
Pan-Cancer Biomarkers
NTRK1        NTRK2        NTRK3        MSI        TMB (Emerging)
Lung Melanoma Colon Ovarian Breast Gastric Bladder Myeloid Sarcoma
AKT1 BRAF AKT1 BRAF AKT1 BRAF MSH5 ABL1 ALK
ALK CTNNB1 BRAF BRCA1 AR KIT PMS2 ASX1 APC
BRAF GNA11 HRAS BRCA2 BRCA1 KRAS TSC1 CALR BRAF
DDR2 GNAQ KRAS KRAS BRCA2 MET   CEBPA CDK4
EGFR KIT MET PDGFRA ERBB2 MLH1   ETV6 CTNNB1
ERBB2 MAP2K1 MLH1 FOXL2 FGFR1 PDGFRA   EZH2 ETV6
FGFR1 NF1 MSH2 TP53 FGFR2 TP53   FLT3 EWSR1
FGFR3 NRAS MSH6   PIK3CA     GATA2 FOXO1
KRAS PDGFRA NRAS   PTEN     IDH1 GLI1
MAP2K1 PIK3CA PIK3CA         IDH2 KJT
MET PTEN PMS2         JAK2 MDM2
NRAS TP53 PTEN         KIT MYOD1
PIK3CA   SMAD4         MPL NAB2
PTEN   TP53         NPM1 NF1
RET             RUNX1 PAX3
TP53             SF3B1 PAX7
TMB             SRSF2 PDGFRA
              TP53 PDGFRB
                SDHB
                SDHC
                SMARCB1
                TFE3
                WT1

The genes and biomarkers listed in this table are a subset of all genes included in the panel. In order to view the full gene list, please download the product datasheet, available under Literature in this page.

* The product to evaluate DNA & RNA variants is the TSO500 DNA/RNA bundle.

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