Transforming modern infectious disease surveillance and outbreak response

NGS offers powerful and comprehensive solutions for infectious disease detection and characterization

Infectious Disease Surveillance and Monitoring

Genomics is transforming modern infectious disease surveillance, expanding our understanding of pathogen evolution, host–pathogen interactions, and antibiotic resistance. In turn, public health professionals are changing the methods they use to research, monitor, and prevent epidemics and pandemics of high-profile infectious diseases such as influenza, tuberculosis, Ebola, and more recently, coronavirus.

Traditional methods of assessing infectious agents include antibody-based testing, real-time PCR, pulsed field gel electrophoresis, and multilocus sequence typing. These methods are typically useful only for a small and defined number of organisms, and data analysis can be subjective. In contrast, next-generation sequencing (NGS) provides a universal, hypothesis-free method for infectious disease surveillance that may be used with viruses, bacteria, fungi, or parasites, and can replace the need for multiple tests. 

Human Microbiome Analysis
Our Perspective on the Novel Coronavirus COVID-19 Outbreak

The severe acute respiratory syndrome coronavirus COVID-19 outbreak is an important reminder that the global community must strengthen national and international programs for early detection and response to future disease outbreaks.

Illumina technology was used as part of front line testing to identify coronavirus. We have made our technology available globally to support applications and strategies to improve detection and to enhance our tracking of the epidemiology, evolution, and virulence of COVID-19.

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Illumina Perspective on the Novel Coronavirus SARS-CoV-2 Outbreak

Find and Characterize Respiratory Viruses with Illumina RNA Prep with Enrichment

A rapid target enrichment sequencing workflow for highly sensitive detection and characterization of respiratory viruses, including COVID-19 strains.

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Targeted Sequencing with the Coronavirus Panel on Illumina Systems

Effective detection of coronavirus using a comprehensive targeted enrichment workflow.

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Illumina RNA Prep with Enrichment Tagmentation Guide

The Illumina RNA Prep Tagmentation with Enrichment kit pairs with an index kit and enrichment panel to generate enriched libraries for dual-indexed, paired-end sequencing.

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This pandemic has underscored the need for new tools to detect, diagnose, and monitor emerging pathogens like SARS-CoV-2. Together with the Illumina respiratory virus oligo probe (RVOP) enrichment panel, this customized Explify RVOP application from IDbyDNA provides a sample-to-result solution for clinical metagenomics.

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Powering Clinical Metagenomics Analysis to Address SARS-CoV-2 Detection
IDbyDNA's Explify Platform Delivers Advanced Insights

The Explify Platform is a fully supported NGS-based, clinical metagenomics technology suite for clinical laboratories. Watch this video for a virtual tour to better understand how the Explify Platform streamlines processes, supports labs, improves results, and much, much more.

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IDbyDNA's Explify Platform Delivers Advanced Insights

Featured Infectious Disease Articles

 
Illumina and IDbyDNA Partner to Deliver NGS Infectious Disease Solutions
Illumina and IDbyDNA Partner to Deliver NGS Infectious Disease Solutions

The partnership aims to accelerate and improve testing for emerging public health threats like SARS-Cov-2.

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Next-Generation Sequencing Helps Fight Infectious Diseases Globally
Next-Generation Sequencing Helps Fight Infectious Diseases Globally

NGS technology enabled infectious disease experts to identify and characterize the genome of the novel coronavirus in China.

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How Sequencing-Based Surveillance Helps Fight COVID-19
How Sequencing-Based Surveillance Helps Fight COVID-19

Chief Medical Officer, Phil Febbo, MD, discusses how public officials follow the path of the epidemic and what that means for tracking the spread of coronavirus mutations.

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Microbes and Metagenomics Research Review

This summary highlights recent peer-reviewed publications in which researchers used NGS to analyze viral populations, microbial pathogenesis, zoonotic reservoirs, the gut microbiome, and more.

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Microbes and Metagenomics Research Review

Genomic analysis with NGS provides high-resolution information to distinguish pathogen strains that differ by as little as one single-nucleotide polymorphism (SNP). It also allows identification of both novel and known infectious agents.

Illumina NGS technology delivers rapid results and high-quality data that public health professionals are utilizing to identify, track, and respond to infectious disease outbreaks.

rRNA Depletion Kits
rRNA Depletion Kits

Depletion of ribosomal RNA (rRNA) prior to RNA sequencing (RNA-Seq) enables researchers to focus on analyzing high-value portions of the transcriptome. 

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TruSeq Stranded Total RNA Library Prep
TruSeq Stranded Total RNA Library Prep

A robust, highly scalable whole-transcriptome analysis (RNA-Seq) solution for a variety of species and sample types, including human, mouse, and formalin-fixed, paraffin-embedded (FFPE) tissue.

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NextSeq System and Reagents
NextSeq System and Reagents

The NextSeq System provides the flexible power you need for whole-exome, transcriptome, and targeted resequencing.

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iSeq System
iSeq System

The iSeq 100 System makes next-generation sequencing easier and more affordable than ever. Labs of all sizes can now easily sequence small genomes, interrogate gene sets, analyze gene expression, and more.

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MiniSeq System
MiniSeq System

The MiniSeq System offers a simple, affordable solution. Advance your research with the power and reliability of proven Illumina NGS technology.

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MiSeq System
MiSeq System

With the MiSeq System you can access focused applications such as targeted resequencing, metagenomics, small genome sequencing, targeted gene expression profiling, and more.

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Targeted Sequencing with the Pan-Viral Panel
Targeted Sequencing with the Pan-Viral Panel

This NGS workflow enables culture-free detection of viral targets without prior knowledge, even for mutagenic regions.

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Illumina NGS Virology Solutions
Virology NGS Solutions

Illumina NGS offers a comprehensive picture of viruses, host interactions, and phages specific to microbes.

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Influenza Surveillance in China

Learn how researchers at the Jiangsu CDC use Illumina NGS for influenza surveillance.

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Reconstructing Tuberculosis Outbreaks
Reconstructing Tuberculosis Outbreaks

NGS was used to reconstruct outbreaks of tuberculosis in British Columbia, Canada.

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Deep Sequencing of HIV
Deep Sequencing of HIV

Learn about detection of drug resistance variants and tracking of viral haplotypes.

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Diagnosing Infectious Disease with NGS
Diagnosing Infectious Disease with NGS

Dr Peyro-Saint-Paul explains how the CE-IVD marked iDTECT™ Blood Test can be used to detect pathogens in blood samples.

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HIV Variant Calling

Discover a streamlined workflow for HIV variant calling.

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